As veterinary medicine industry has grown up steadily, the government quality control of veterinary medicine in market has been performed since 1964. The result of post-market surveillance assay from 2009 to 2012 was analyzed in this study. The average violation rate of all veterinary medicines, was 3.2%, 2.8%, 2.8% and 1.4% in 2009, 2010, 2011 and 2012, respectively. The total average violation rate in the category of antibiotics, other drugs except antibiotics, biologics were 1.2%, 4.4% and 0.8%, respectively. The violations due to insufficiency of major active ingredient content occupied 76.7% among the total violations. The most frequent violated in antibiotics were ampicillin and tylosin, followed by sulfonamides, penicillins etc. In case of other drugs except antibiotics, vitamin A and glucocorticoids (dexamethasone and prednisolone) were violated frequently. The overall trend of violation rates gradually decreased from 2009 to 2012, suggesting that quality of veterinary medicines has improved according to Korea Veterinary Good Manufacturing Practice (KVGMP) system settled down in 1988.

Rabies is a zoonotic disease that causes severe destruction to the central nerve system which is usually fatal. It is one of the most important disease around the world and particular in Asia because of the high costs of prevention and post-exposure treatment. After the recurrence of sylvatic rabies in 1993, the number of raccoon dog mediating rabies cases in Korea has maintained annually until 2011. To better understand the current rabies epidemics in Korea, Korean rabies isolate (SKRBV0601GY) from Gyeonggi province in 2006 was compared with previous isolates in Korea and with isolates originating from the North-East Asia, such as Japan, China and Russia, based on complete nucleoprotein (N) gene sequences. By comparison of the N genes among these viruses, SKRBV0601GY revealed that nucleotide similarity ranged from 97.7 to 99.7%, 96.4 to 97.5%, 91.4 to 96.3%, 89.2 to 90% and 86.1 to 88.1% with Korean isolates, "Arctic-like-2" viruses, "Arctic" viruses, Russian group C - E and Chinese isolates, respectively. Phylogenetic analyses of the isolates revealed that the Korean isolate in 2006 belonged to Korean group B. The topology of the phylogenetic tree of Korean isolates related not the species and year of isolation but the geological location of the virus isolates. All of the Korean isolates showed close relationship to the "Arctic-like-2" virus (Russian group B) more than the "Arctic" virus (Russian group A) and all of the Chinese isolates (Chinese group A, B and C). The "Arctic-like-2" virus group contains the Japanese isolate and Russian group B viruses, originating from the south of East Siberia and Far East in Russia. These molecular data demonstrated that the current rabies epizootic in Korea developed independently of Chinese groups and originated from the "arctic-like-2" viruses in detail.

Ruminant pestiviruses of bovine viral diarrhea virus (BVDV) and border disease virus (BDV) are closely related to classical swine fever virus (CSFV) and all belong to the genus of Pestiviruses. BVDV is one of the most important viral pathogen of cattle and has been recorded in most countries where cattle are raised. Natural host for BVDV is cattle, but BVDV is able to infect pigs as well. The purpose of this study was to investigate the prevalence for antibodies against BVDV in domestic pig farms in South Korea from 2009 to 2011. In this study, 2,755 pigs in 239 farms in South Korea's inland and 5,293 pigs in 613 farms in Jeju province (CSF free region) were investigated for antibodies against two pestiviruses, BVDV and CSFV by a virus neutralization test (VNT). The seroprevalences on the individual level and on herd level against BVDV were 5.3 % and 21.2 % in South Korea's inland, 5.2 % and 6.5 % in Jeju province, respectively. Based on the ratio of respective antibody titers by the comparative VNT, 273 pigs in Jeju province with BVDV infection were detected and they were distinctly negative to CSF. It is recognized that porcine infections with BVDV naturally occurred in Jeju province. Whereas, antibody titers against BVDV of South Korea's inland were cross-reactivity with CSFV.