목적 : 본 연구에서는 코로나19 이전과 이후 10대 청소년의 근시 진행 정도를 비교하여 알아보고자 하였다 방법 : 본 연구는 전북 전주시에 있는 안경원을 방문한 코로나 이전과 이후 14~16세 청소년을 대상으로 안질 환이 없고 연1회 이상 방문하여 기록된 안경처방서를 분석하였다. 코로나 이전과 이후 각각 3년간 추적조사한 굴 절이상 변화는 RM(repeated measures of ANOVA))을 사용하여 분석하였다. 결과 : 코로나19 전과 후 안경처방서를 3년간 추적하여 분석한 결과 오른눈이 왼눈보다 근시 변화량이 크게 나 타났다. 연령별 굴절이상도에서 코로나 이전은 14세에서 가장 높게 나타났고, 코로나 이후는 15세에서 가장 높게 나타났다. 근시 진행 속도는 코로나 전후 모두 14세에서 가장 큰 폭으로 증가하였다. 코로나 이전과 이후 연구대 상자의 회차별 등가구면 굴절이상 변화량을 1차년도와 3차년도를 비교한 결과 코로나 이전은 –0.68±0.52 D였으 며, 이후는 –1.01±0.55 D로 코로나 이후 근시가 매우 증가하는 것으로 나타났다. 결론 : 본 연구에서는 코로나 이전보다 이후 10대 청소년의 근시 진행이 빠른 속도로 진행되는 경향을 보였으 며, 이에 대한 다양한 원인을 찾는 지속적인 연구가 필요하다. 추후 청소년의 시력저하 및 근시 진행을 예방하기 위해 국민 안보건 복지 차원에서 계속적이고 추가적인 연구를 시행할 것을 제안한다.

This study attempted to verify the possibility of using germ cell aspiration (GCA) method as a non-fatal technique in studying the life-history of equilateral venus, Gomphina veneriformis (Veneridae) and granular ark, Tegillarca granosa (Arcidae). Using twenty-six gauge 1/2" (12.7mm) needle, GCA was carried out in equilateral venus through external ligament. In granular ark, GCA was performed by preventing closure of the shells by inserting a tongue depressor between the shells while still open. The success rate of sex identification using the GCA method was 95.6% for the equilateral venus (n=650/680) and 94.3% for the granular ark (n=707/750). Mortality of equilateral venus, which spent 33 days under wild conditions, was 13.8% (n=90/650) while the mortality of granular ark, which spent 390 days under wild conditions, was 2.4% (n=17/707). Although we believe that GCA does not appear to cause death in equilateral venus or granular ark, the success rate in employing of this methodology may differ depending on the level of proficiency of the researcher and reproductive stage of the bivalve. This study concludes that GCA is a convenient non-fatal methodology, which can be employed to identify sex and investigate gonadal maturity in Gomphina veneriformis and Tegillarca granosa.

Two compounds from Gomisin N and Gomisin A were isolated from the fruits of Schizandra chinensis Baillon. The highest extraction yield as 21.36% was observed in the ethanol extract, compared to the yield obtained form the water extract. The extraction yields of the single compounds were measured to be 0.13 and 0.014 Gomisin A and Gomisin N, respectively. Approximately, 90% of the growth of human stomach adenocarcinoma cancer cells was inhibited after adding 1.0 g/l of the ethanol extract. The growth of the human normal lung cell was limited to 24% after adding the ethanol extract. The water extract lowered the specific secretion of TNF-á and IL-6 from T cells, 10.3×10-4 pg/cell and 12.1×10-4 pg/cell, respectively, compared to the ethanol extracts. On the other hand, a treatment with the ethanol extract increased the specific secretion of TNF-á and IL-6 from human T cells, to 11×10-4 pg/cell and 14.3×10-4 pg/cell, respectively. The crude ethanol extract had the highest effect on the differentiation of human promyelocytic leukemia cells compared to the other extracts and Gomisin A and N. In general, the biological activities of the extracts gradually decreased as the purification process proceeded, which suggests that higher immunostimulatory activities can be maintained by adding the crude extracts of the fruits rather than by adding a single compound.