Paradental cysts characteristically develop adjacent to the cervical margin on the lateral aspect of a tooth root and result from inflammatory processes within the periodontal pocket. Standard management usually involves cyst enucleation while striving to retain the affected tooth. Recurrence rates are infrequent following complete removal of the lesion. However, intentional replantation becomes necessary in cases with anatomical constraints or accessibility issues. We present the case of a 13-year-old female patient exhibiting delayed eruption of the mandibular left second molar, attributed to a cystic lesion located on the lingual-coronal aspect of the tooth.

Enamel knot (EK)—a signaling center—refers to a transient morphological structure comprising epithelial tissue. EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26 , Fat4, Meis2, Sln , and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.