In insects, the glutathione S-transferase is initiated in both the detoxification process and the protection of cellular membranes against oxidative damage. In this study, we identified the open reading frame (ORF) sequence of GST-iso1 and 2 from Tenebrio molitor (TmGST-iso1 and 2). To investigate the expression patterrns of TmGST-iso1 and 2 in response to herbicide, 0.06, 0.6, and 6 ㎍/㎕ of butachlor (FarmHannong, Seoul, South Korea) was challenged into T. molitor larvae, resulting that the TmGST-iso1 were highly induced at 3 and 24 h-post injection. Whereas, the highest expression of TmGST-iso2 was detected at 24 h after treatment. This study may contribute to basic information about the detoxifying activities of T. molitor.

It is well known that the JNK pathway regulates AMP production against pathogenic infection in both vertebrates and invertebrates. Tenebrio molitor hep (Tmhep) is an homolog of MAP kinase kinase in mammals. Here, we investigate the immunological function of Tmhep in responses in microbial infection using RNA interference technology. The results showed that silencing of Tmhep increased the larval mortality against microbial challenge, as well as reduced AMP production compared to the control group (dsEGFP-treated group). Conclusively, Tmhep plays an critical role in antimicrobial defense in T. molitor larvae.

최근 IT기술의 발전과 기술융합으로 다양한 기술이 급속하게 변화하고 있다. 이에 따라 정부에서도 중장기 전략적 기술개발 목표를 달성하기 위해 필요한 기술을 발굴하고 기술로드맵을 제시하고 있다. 국방에서는 무기체계 중심으로 국방과학기술 기획 프로세스를 정립하였으나, 국방 IT 분야는 아직 그 틀이 마련되지 못했다고 할 수 있다. 이에 따라, 본 논문에서는 국방 정보기술 환경분석을 통한 국방정보화 전망을 제시하였고, 국방 정보기술 조사·분석 방법론을 통한 미래 유망 국방정보기술을 발굴하고, 국방 정보기술 기획 발전 방안을 제시하였다.