The current standard treatment regimen for patients with cervical cancer consists of a combination of radiotherapy and chemotherapy. However, the serious side effects often encountered with chemotherapy drugs greatly limits the effective doses that can be delivered, and hence the treatment of cervical cancer still faces strong challenges. In this study, carbon nanodots, nanodrugs with anti-cervical cancer activity and with negligible toxicity, were prepared from the precursor herbal extract ginsenoside Rg1. The surface of the Rg1 carbon nanodots is rich in hydrophilic functional groups, resulting in good dispersion in aqueous media and high biocompatibility. In Vitro experiments show that the Rg1 carbon nanodots have significant cytostatic and pro-apoptotic effects on HeLa cells, and could inhibit their migration and invasion. Experiments in tumor-bearing nude mice show that the Rg1 carbon nanodots could significantly inhibit tumor growth. Through qPCR validation, the Rg1 carbon nanodots were shown to enhance HeLa cell apoptosis, by regulating the expression levels of Cyto c, Caspase-9, Caspase-3, Bax, and Bcl-2, induce G2/M phase arrest by regulating CDK 1 and Cyclin B1 expression, and inhibit tumor cell migration by modulating CDH1 and β-catenin. Since the precursor Rg1 is a natural herbal extract, negligible toxic side effects were observed in nude mice. The work demonstrates that Rg1 carbon nanodots can be expected to become a potential nanomedicine against human cervical cancer with negligible toxic side effects and excellent therapeutic effects.

In the context of the pan entertainment era, the IP economy has unleashed infinite vitality and brought infinite possibilities to China’s animation market. With the help of the IP economy, China’s anime works will achieve three-dimensional and multi-dimensional development, and also be endowed with emotional needs, establishing an intangible bond with users. This article will explore how Chinese anime works can present a visual feast that combines Chinese characteristics and aesthetics under the IP economy model.

With the continuous rise of China-Chic culture in recent years, a cultural atmosphere with Chinese characteristics has poured into people’s minds. The emergence of Chinese cartoon has also led to a new trend in China’s animation derivatives. Animation derivatives are an indispensable part of the cultural and creative industries. The creation of relevant brands of China’s animation derivatives can reshape the cohesion of the animation derivatives industry, but China’s animation derivatives brands lack fresh blood. This article will discuss how Chinese animation derivatives, under the influence of China-Chic culture, can be put into the brand design boom with national flavor.