Skeletal muscle is an organ that regulates biological metabolic energy. Its dysfunction causes decline of body functions and disability, thus deteriorating the overall quality of life. Various materials are being developed with an anti-sarcolytic effect. However, anti-sarcolytic effect of Sinomenium acutum rhizomes extract (SAE) remains unclear. Therefore, this study aimed to investigate anti-muscle atrophy effects of SAE and its alkaloids, including sinomenine (SIN), magnoflorine (MF), acutumine (ACU), and N-ferultyramine (NFT) isolated from SAE, on dexamethasone (Dex)-induced myotubules. C2C12 myogenic cells differentiated for 6 days were treated with 1 mM Dex for 24 hours. Induction of muscular atrophy was confirmed by a decrease in myogenin expression. We found that Dex increased expression levels of muscle-specific ubiquitin ligases MuRF1 and MAFbx/atrogin-1. However, mRNA and protein levels of these muscle-specific ubiquitin ligases were significantly reduced by cotreatment with SIN, MF, and NFT in myotubes. Glucose uptake reduced by Dex in myotubules were also restored by SIN, MF, and NFT treatments. These results suggest that SIN, MF, and NFT can reduce muscle wasting and enhance glucose uptake in Dex-treated myotubes, highlighting their potential as therapeutic agents to prevent muscle atrophy.

본고에서는 고대 중국에서 ‘술수, 방기(術數, 方技)’의 내용과 변천을 검토하고 ‘술 수, 방기’가 백제(百濟)에 전파된 사상적 배경, 시대적 배경 그리고 전파 경로를 중심 으로 살펴보았다. ‘술수, 방기’가 백제에 전해지기 전에 우리나라는 이미 ‘술수 방기’ 가 뿌리 내릴 수 있는 사상적 배경과 토양을 가지고 있었다. 고대 중국의 ‘술수, 방 기’는 당시 일종의 선진문화로서 직접 및 간접적 경로를 통해 백제에 전파되었다. 백 제는 중국에서 들여온 ‘술수, 방기’의 문화를 흡수하고 자국 상황에 맞게 변용하고 적용했을 뿐 아니라, 더욱 발전시켜 일본에도 전파하였다.