Recently, most of moving parts at automobile engine are required to be lighter and compacter and have high performances such as strength and endurance, etc. In particular, the crankshaft is subject to complex loadings such as shear, bending, and torsional loads as well as inertia and torsional vibration. To investigate critical area and optimize the shape of crankshaft at intial design stage, it is necessary to consider the dynamic effect of crankshaft. This paper carried out structural analysis of engine crankshaft by using multi-body dynamics and multi-axial fatigue analysis