Water cycle within the human civilization has become important with urbanization. To date, water cycle in the eco-system has been the focus in identifying the degree of water cycle in cities, but in practicality, water cycle within the human civilization system is taking on an increasing importance. While in recent years plans to reuse water have been implemented to restore water cycle in cities, the effect that such reuse has on the entire water cycle system has not been analyzed. The analysis on the effect that water reuse has on urban areas needs to be go beyond measuring the cost-savings and look at the changes brought about in the entire city’s water cycle system. This study uses a SWAT model and water balance analysis to review the effects that water reuse has on changes occurring in the urban water cycle system by linking the water cycle within the eco-system with that within the human civilization system. The SWAT model to calculate the components of water cycle in the human civilization system showed that similar to measured data, the daily changes and accumulative data can be simulated. When the amount of water reuse increases in urban areas, the surface outflow, amount of sewer discharge and the discharged amount from sewage treatment plants decrease, leading to a change in water cycle within our human civilization system. The determinant coefficients for reduced surface outflow amount and reduced sewer discharge were 0.9164 and 0.9892, respectively, while the determinant coefficient for reduced discharge of sewage treatment plants was 0.9988. This indicates that with an increase in water reuse, surface flow, sewage and discharge from sewage treatment plants all saw a linear reduction.