Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as Parkinson’s disease, Alzheimer’s disease, epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. The EtOH extracts of Viola mandshurica (NNMBS274), Viola patrinii (NNMBS275) and Viola papilionacea Pursh (NNMBS276), origin plants of Violae Herba, showed the potent neuroprotective effects on glutamate-induced neurotoxicity. Among them, NNMBS275, the extract of V. patrinii possessed the protective effects against glutamate toxicity by inducing the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells. These results suggest that extracts of V. patrinii could be the effective candidates for the treatment of ROS-related neurological diseases. Furthermore, it is suggested that the protective effects of V. patrinii extract due to inducing the expression of HO-1 as an antioxidant/cytoprotective target

본 연구는 한방생약재로 사용되고 있는 자화지정의 식품학적 가치와 식품소재로서의 개발 가능성을 검토하기 위하여 국내에서 채집된 자화지정의 기원식물인 제비꽃과 한방재료로 유통, 판매되고 있는 중국산 자화지정을 비교, 분석하였다. 분석 결과 자화지정 꽃의 환원당과 유리당이 각각 10,485.11 mg%와 118.85 mg%로 가장 많았으며, 수용성 단백질과 폴리페놀의 함량도 각각 1,259.26 mg%와 2366.67 mg%로 함량이 높은 것으로 확인