Pipe for water supply is one of the important parts that supply water to home, factory and so on. Water leakage in pipe for water supply due to deterioration, ground sinking and earthquake leads to enormous economical loss. Therefore, pipe for water supply should be designed to satisfy the requirement of, for instance, structural stability and fatigue durability. The purpose of this study was to investigate the fatigue durability of flexible joint for relaxing the impact due to earthquake and ground sinking. For this purpose, flexible joint was simulated using dynamic characteristics and fatigue life. As the results, the problem of fatigue durability may occur when flexible joint and pipe for water supply are treated as rigid body in simulation. Thus it means that the role of packing in flexible joint is very important and packing should be designed as optimal conditions that are considered fatigue durability as well as waterproof.