In the present study, silver-doped antibacterial hydroxyapatites were successfully prepared by the sol-gel method. For the starting solution, the molar ratio of was set to 0.075:0.045:20:0.135; was added to a ratio of Ag to total cation concentration of . The prepared sol was dried at for 48h and heat-treated at for 2h to obtain particles in the 200-500nm size range. The product from the synthesis of silver-doped hydroxyapatite was investigated through X-ray diffraction experiments and scanning electron microscopy. The product showed high antibacterial properties, with a disinfection ratio of Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 25922) over as calculated from an antimicrobial effects evaluation by the shake flask method.

Ag doped Hydroxyapatite powder in nano-scale was successfully synthesized either by co-precipitation or by ion exchange route. The fabricated powder was successfully dispersed through freeze drying due to the prevention of secondary particles. The antimicrobial effects of nano-HAp against E.coli was superior to micron ones not only in its strength but also in duration.