Parotid gland ancient schwannoma is an extremely rare entity, with only 6 cases reported to date. Ancient schwannoma present degenerative alteration, including cystic changes, hyalinizing stroma, hemorrhages, infiltration of macrophages, and cellular atypia with hyperchromatic nuclei. These factors have the potential to mimic malignant tumors, resulting in an overestimation of diagnosis and subsequent inappropriate management. In the present case, we report a case of parotid gland ancient schwannoma, which developed relatively fast degenerative alteration without a large-sized mass. We reviewed all the cases of parotid ancient schwannoma, and suggest that the character of parotid gland tissue can deceive the change of tumor growth size. We also suspect that pre-surgical manipulation, such as FNAB or CNB, can cause degenerative changes in a relative short period. It is important to consider reactive degenerative alteration of schwannoma, and not to misinterpret as a malignant entities, notably when needle biopsy history is present.

Schwannoma, benign neoplasia derived from schwann cell, is rare tumor, and prevalent in tongue, palate, floor of mouth and buccal mucosa. Thirty-six-year-old male with asymptomatic protrusion of mandible angle was evaluated. We surgically removed the mass and histological examination gave the diagnosis of ancient schwannoma. We report a case of ancient schwannoma in masseter muscle and review of literature.