Clear cell odontogenic carcinoma (CCOC), a very rare neoplasm located mostly in the mandible, has been regarded as a benign tumor. However, due to the accumulation of case reports, CCOC has been reclassified as a malignant entity by the World Health Organization. Patients with CCOC present with regional swelling and periodontal indications with variable pain, often remaining misdiagnosed for a long period. CCOC has slow growth but aggressive behavior, requiring radical resection. Histologic analysis revealed the monophasic, biphasic, and ameloblastic types of CCOC with clear cells and a mixed combination of polygonal and palisading cells. At the molecular level, CCOC shows the expression of cytokeratin and epithelial membrane antigen, along with markers that assign CCOC to the sarcoma family. At the genetic level, Ewing sarcoma breakpoint region 1-activating transcription factor 1 fusion is regarded as the key feature for identification. Nevertheless, the scarcity of cases and dependence on histological data delay the development of an efficient therapy. Regarding the high recurrence rate and the potential of distant metastasis, further characterization of CCOC is necessary for an early and accurate diagnosis.

Clear cell odontogenic carcinoma (CCOC) is an extremely rare odontogenic neoplasm; Only a few cases have been reported in the English literatures. It displays a propensity for the mandible, most commonly presenting in the fifth to seventh decades, with a female predilection. The clinical and radiological manifestations are multiple and the diagnosis is histological. Histological feature is of large islands and strands of uniform cells with round or ovoid nuclei and clear cytoplasm. Clinically, painless swelling is the most common symptom, followed by pain, teeth mobility, and paresthesia. CCOC has a good prognosis after surgery. This case report presents the histopathological and clinical features of CCOC excised from the mandible.

Clear cell odontogenic carcinoma (CCOC) is a very rare malignant neoplasm of jaw, with a significant clear cell component. It is nearly three times as common in the mandible with distinct female predominance. Past, identified as locally invasive tumor, CCOC is now considered to be malignant neoplasm, showing distant and regional lymph node metastasis. CCOC is histopathologically characterized by large glycogen-rich clear cells, often intermixed with eosinophilic cells. When diagnosing CCOC, ruling out salivary gland tumors, such as mucoepidermoid carcinoma or clear cell adenocarcinoma is important because they have overlapping histologic features with CCOC. Here in, we report a case of CCOC involving the right maxillary sinus of a 72-year-old female.

Clear cell adenocarcinoma (CCA) is a rare malignant neoplasm of salivary gland that represents only 1% of all salivary gland tumors. CCA is histopathologically characterized by monotonous, glycogen-rich, round to ovoid clear cells intermixed with hyalinized stroma. However, other salivary gland tumors such as mucoepidermoid carcinoma, acinic cell adenocarcinoma, oncocytoma, epithelial-myoepithelial carcinoma, and myoepithelial carcinoma should be ruled out to diagnosis CCA. We herein report a case of CCA involving the soft palate in a 56-year-old female. It is essential to consider CCA in the differential diagnoses of clear cell tumors.

Al thou gh calcifi cation is a common finding in inflammatory salivary gland disorders , saliva ry gland tumour ra rely s hows calcifications. A case of clear cell mucoepidermoid carcinoma(MEC) of the hard pa late with extensive intra tumoural calcifïcations vis ible on computed tomog r때hy(CT) scans and histologic sections is described. The calci fï caLion in the sali va ry gland tumour 0 1' the palate recogni zed by a CT scan s hould be considered in the differential diagnosis of a MEC The mechanism of the i ntratumoural calcifi cation in our case is speculated to be a result of a secretory fu nction 0 1' the tumour cells

A case of odontogenic ghost cell tumor (OGCT) with clear cell components occurred in the mandible of a 63-yearold man. The tumor revealed ameloblastomatous type epithelial components together with clusters of ghost cells and dentinoid juxtaposed to the odontogenic epithelium. In addition, some areas of the tumor tissue showed sheets and islands of clear, glycogen-rich epithelial cells, separated by a thin fibrous connective tissue stroma. Both ameloblastic and clear cells showed positive immunoreactivities for cytokeratin 19 and AE1/3. It is not known whether this tumor represents a clear cell differentiation of a preexisting OGCT or a separate and distinct neoplasm derived de novo from odontogenic epithelium. This tumor was preferred the term clear cell odontogenic ghost cell tumor, which captures the clear cell components, one of the tumors most prominent distinguishing features