Helicobacter pylori are known as a causative agent of gastritis, gastric duodenum and peptic ulcer, and gastric cancer, and multiple drug use is associated with various side effects in patients. The discovery of antibacterial substances against H. pylori from Korean resource plants is an important substitute for antibiotics. 52 species of Korean resource plants were collected and extracted with 50% ethanol, and antibacterial activity against H. pylori was measured using the disk diffusion method. The toxicity of plant extracts to human gastric adenocarcinoma(AGS) cells was measured by MTT assay, and the level of IL-8 secreted when gastric epithelial cells were inoculated with H. pylori was measured. As a result of measuring the antibacterial activity of H. pylori, antibacterial activity was confirmed in 38 plant extracts. The plant species with the strongest antibacterial activity were Chrysanthemum indicum, Rheum rhabarbarum, Patrinia scabiosaefolia and Petasites japonicus. C. indicum was not cytotoxic to H. pyroli-infected AGS cells and showed anti-inflammatory effects. This study's results can be used to develop healthy, functional foods and medical materials.

The effects of β-lapachone on gastric secretion were investigated. The pylorus of male Sprague-Dawley rats was ligated and intraduodenally injected with β-lapachone, and the volume, pH, free HCl, and total acidity of gastric fluid were measured 6 hours after the operation. Treatment with β-lapachone resulted in dose-dependent inhibition of gastric secretion Gastric fluid was reduced to 42.9% of control level by 100 mg/kg of β-lapachone, leading to an increase of pH to 6.70 from 1.85 in the control group. In parallel with the increase of pH, at this dosage, free HCl and total acidity decreased to 16.7% and 12.0%, respectively, of control levels. β-Lapachone exhibited ED50 values of 72, 46, and 47 mg/kg for inhibition of gastric volume, free HCl, and total acidity, respectively, implying a superior efficacy on gastric acid to volume. In comparison, pantoprazole (30 mg/kg) reduced the volume, free HCl and total acidity of gastric fluid to 53.0%, 26.0%, and 25.0%, respectively, of control levels, resulting in an increase in pH to 6.36. In the current study, it was confirmed that β-lapachone at an appropriate dose (100 mg/kg) exerted a higher inhibitory effect on gastric secretion than pantoprazole (30 mg/kg), a well-known proton-pump inhibitor. Therefore, it is suggested that β-lapachone could be a candidate compound for prevention or treatment of gastric ulcers induced by diverse psychological and physical stimuli.

식물에서 얻어지는 정유의 한 성분으로 화학구조가 유사한 anethole, eugenol, isoeugenol, safrole 및 isosafrole이 위액분비 및 위운동에 미치는 영향을 알아보기 위하여 위액분비는 rat를, 위운동은 비둘기를 이용하여 실험을 행하였던 바 다음과 같은 결과를 얻었다. 1. 1% anethole을 rat의 체중 100g당 각각 , 및 의 비율로 복강내로 투여하였던 바, 6마리씩의 평균 위액분비량이 각각 , 및 로서 대조군에 비하여 각각 70.8%, 41.0% 및 12.2%의 위액분비 억제율을 나타내었다. 2. 1% eugenol을 rat의 체중 100g당 각각 , 및 의 비율로 복강내로 투여하였던 바, 6마리씩의 평균 위액분비량이 각각 , , 로서 대조군에 비하여 각각 77.9%, 39.1% 및 37.6%의 위액분비 억제율을 나타내었다. 3.1% isoeugenol을 rat의 체중 100g당 각각 , 및 의 비율로 복강내로 투여하였던 바, 6마리씩의 평균 위액분바량이 각각 , , 및 로서 대조군에 비하여 각각 53.6%, 46,0% 및 33.4%의 위액분비 억제율을 나타내었다. 4.1% safrole을 rat의 체중 100g당 각각 , 및 의 비율로 복강내로 투여하였던 바, 6마리씩의 평균 위액분바량이 각각 , , 및 로서 대조군에 비하여 각각 62.1%, 36.2% 및 13.0%의 위액분비 억제율을 나타내었다. 5.1%의 isosafrole을 rat의 체중 100g당 각각 , 및 의 비율로 복강내로 투여하였던 바, 6마리씩의 평균 위액분비량이 각각 , 및 로서 대조군에 비하여 각각 86.3%, 67.2% 및 38.6%의 위액분비 억제율을 나타내었다. 한편, 이들 다섯가지 정유들의 1% 유제용액을 각각 비둘기의 체중 100g당 를 복강내로 투여하였던 바, 정도의 차이는 있으나 모두 비둘기의 위운동을 억제하였다. 이상의 결과로서 이들 다섯가지 정유 모두는 rat의 위액분비를 억제하며, 비둘기의 위운동을 억제하는 작용이 있음을 알았다.