Extranodal intraoral Hodgkin lymphoma is not common. We report the case of a 78-year-old male patient with ulcer of the mandibular oral mucosa that was not cured for about 3 weeks. In biopsy and histopathologic examination, it was found to be extranodal intraoral Hodgkin lymphoma. Early diagnosis of oral lesions led to early detection of lesions of the opposite neck lymph node in an additional PET-CT scan. We report this case and review relevant literature.

Development of two different histologic types of lymphoma in the same person is rare. Sequential lymphoma is defined as two different types of lymphoma occurring sequentially in the same person. In particular, sequential Hodgkin’s lymphoma (HL) following non-Hodgkin’s lymphoma (NHL) is extremely rare. A 63-year-old female diagnosed with B-cell NHL at the mass in T3 received treatment with an R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) protocol for six cycles. However, 12 months later, the patient complained of a left neck mass and excisional biopsy was performed. Microscopically the biopsied tissue showed Reed-Stemberg cells and confirmed the diagnosis of HL. The patient was treated with ABVD (adriamycin, bleomycin, vinblastine and dacarbazine) for four cycles. Although the possibility of a secondary malignancy cannot be excluded, this is a rare case of sequential Hodgkin’s lymphoma following Non-Hodgkin’s lymphoma.