Common benign oral soft‑tissue lesions include irritation fibroma and cemento‑ossifying fibroma (COF). Complete surgical excision is the standard treatment. We describe two cases where the overlying oral mucosa was recycled as an autologous free mucosal graft to cover the surgical defect. In both cases, the lesions were excised with tumor‑free margins. The overlying mucosa was dissected, trimmed, and adapted as a free mucosal graft to cover the defect, fixed with sutures to minimize micromotion. A soft diet and hygiene instructions were provided. This report highlights two cases where the overlying normal oral mucosa was preserved as a free mucosal graft after complete excision of irritation fibroma and cemento‑ossifying fibroma. The technique respected the principle of complete excision, avoided additional donor‑site morbidity, and achieved favorable tissue integration. While prior literature described these lesions as submucosal nodules covered by normal mucosa, systematic use of the preserved mucosa for reconstruction has not been reported. However, this report have limitations, including the small sample size and restricted follow‑up. A free mucosal graft from overlying oral mucosa may be a simple, cost‑effective, and practical option for reconstruction of small to medium intraoral defects when appropriately indicated.

thus, resembles scar tissue. TGF-β1, MMP and TIMP play an essential role in remodeling extracellular matrix during scar formation. This study investigates the pathogenesis of IF with respect to the coordinated expression of factors involved in wound healing. Proliferative activity and expression of TGF-β1, MMP-1 and TIMP-1 were observed using immunohistochemistry in 88 cases of IF and 9 cases of normal oral mucosa(NOM). Proliferative activity and expression of TGF-β1 and TIMP-1 were increased in IF compared to NOM. MMP-1 expression was not significantly increased in IF. We propose that IF is caused by increased expression of TGF-β1 and an imbalance in expression of MMP-1 and TIMP-1.