Hyaluronic acid is natural polysaccharide existing around skin or cartilage, and is known as a moisturizing factor. It is expected that hyaluronic acid cosmetics market will continue to grow in the future, as its use and demand increases, like medical supplies and health food besides cosmetics containing hyaluronic acid. However, There are few present studies on content in cosmetics containing hyaluronic acid. The purpose of this study was to evaluate satisfaction and examine what effect was produced on sebum and moisture in skin after applying to cosmetics the hyaluronic acid helpful in maintaining moisture in skin at 5%, 20% and 50% concentration. For 71 days, a clinical trial in a total 39 persons living in the national capital region was carried out. And sebum and moisture was measured through skin diagnosis system A-ONE TAB before trial and each day when clinical trial was conducted for hyaluronic acid content group. Besides, this study was to examine subjects' general characteristics, eating habits, and living habits, and satisfaction after the clinical trial. This study analyzed a difference according to the time to measure the skin condition among hyaluronic acid content groups by utilizing statistical package program SPSS v. 21.0 through data coding and data cleaning process. There was no statistically significant difference in hyaluronic acid content according to any of demographic characteristics, eating habits and living habits among groups (p>.05). With regard to hyaluronic acid content, there was no statistically significant difference in moisture and sebum prior to clinical trial in T zone and U zone among groups (p>.05). A change of moisture in T zone among groups according to hyaluronic acid content showed statistically significant difference in the 2nd week (F =3.636, p<.05). And the highest level was shown in 50%(44.15±2.672), being followed by 20%(43.15±2.340), and 5%(41.62±2.219). Accordingly, it was shown that, as hyaluronic acid content relatively increased, the moisture in T zone increased. In the results of analyzing the change of moisture in U zone, the change of sebum in T zone and U zone by group according to hyaluronic acid content, no statistically significant difference was shown in sebum level of T zone by group(p>.05). For analyzing the subjective satisfaction after clinical trial among groups according to hyaluronic acid content, satisfaction score was the highest in 'skin moistness' (4.38±0.650) for 5% group, 'skin moistness' (4.69±0.480) for 20% group and 'skin texture smoothness' (4.54±0.519) for 50% group. And no statistically significant difference was shown in each subjective satisfaction by group according to hyaluronic acid content(p>.05). It was thought that the results of skin condition and subjective satisfaction survey according to hyaluronic acid content would be baseline data for developing cosmetics containing the hyaluronic acid and marketing a skin moisturizer.

Skin barrier function can be assessed non-invasively, including by transepidermal water loss (TEWL), skin hydration, and sebum level. The aim of this study was to evaluate day-to-day variation in measurements of TEWL, skin hydration, and sebum level at various anatomic sites and the relationship between these parameters in normal dogs. Measurements were repeated five times on two separate days in five clinically normal Beagle dogs at seven anatomic sites, i.e., the left and right pinnae, left and right axillae, left and right groin areas, and ventrum. Coefficient of variation was used to show the variation in measurements. Correlations between each of the measurements were analyzed to determine the contribution of skin hydration and sebum level to TEWL. There was no variation in the measurements obtained according to time or anatomic site (P>.0.05). The coefficient of variation was highest for sebum level (209.0 ± 81.8%) followed in descending order by skin hydration (62.7 ± 34.5%) and TEWL (41.1 ± 6.9%). Of the seven anatomic sites sampled, the left and right pinnae showed the lowest variation in repeated measurements for TEWL (39.2%), skin hydration (29.6%), and sebum level (75.5%). There was no significant relationship between the results for each measurement (P>.0.05). Because of its relatively low variation on repeated measurement, TEWL might be the most useful way of evaluating skin condition in dogs.

Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95. the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

본 연구에서는 연령별 수분함유량, 유분함유량 및 경표피수분함유량에 대한 데이터를 비교 분석함으로써연령별 피부 특성 차이를 규명하여 향후 화장품 산업개발에 도움을 줄 수 있는 기초자료를 제공하고자 한다.피험자 남녀 총 638명을 대상으로 볼 부위의 수분함유량, 코 끝 부위의 유분함유량, 볼과 전박부위의 경표피수분손실량을 측정하였으며, Statistical Package for the Social Sciences (version 19.00; SPSS Inc.,Chicago, IL, USA) 프로그램을 사용하여 분석하였고 피험자에 대한 정보뿐 아니라 피부 수분함유량, 유분함유량, 경표피수분손실량의 피부 측정치 결과를 평균 ± 표준편차로 나타내었다. 그 결과 볼 부위의 수분함유량은여성이 남성보다 높았으며, 연령이 높아질수록 수분함유량이 증가하였다. 또한 코 부위의 유분함유량은 남성이여성보다 높았으며 연령이 낮아질수록 유분함유량이 증가하였다. 볼 부위의 경표피손실량은 여성이 남성보다높은 반면, 전박 부위의 경표피손실량은 남성이 여성보다 높았다. 이상의 연구 결과로 추후 화장품 산업에서 연령별, 성별 기초화장품 개발 등에 도움을 줄 수 있는 기초자료로 활용될 수 있을 것이라 사료된다.