This study was carried out to investigate the presence of a correlation between heavy metals in urine samples and upper airway diseases. For the study, 51 household residents of Gwangyang, both with and without upper airway disease, were targeted. Urine samples were collected from the subjects along with a questionnaire from April 24th to 27th, 2017. The heavy metals in the urine samples were preprocessed and analyzed using an inductively coupled plasma/mass spectrometer. The geometric mean concentration of urinary arsenic and cadmium was 138.66 μg/L and 0.75 μg/g creatinine among those with upper airway disease and 166.42 μg/L and 1.19 μg/ g creatinine among those without upper airway disease. This was not a statistically significant difference. The concentration of urinary arsenic and cadmium was found to be increased by 1.19 times (95% CI; 0.15-9.31) and 1.26 times (95% CI; 0.31-5.04) in household residents with upper airway diseases with more than 144.86 μg/L and 0.85 μg/g creatinine, respectively.