The present study describes the preliminary evaluation of the anti-inflammatory activities of Phellinus linteus (PL) and Phellinus linteus Grow in Germinated Brown Rice (BRPL). In order to effectively screen for anti-inflammatory agents, we first examined the extracts' inhibitory effects on the expression of pro-inflammatory cytokines activated with lipopolysaccharide. Moreover, we examined the inhibitory effects of the PL and BRPL extracts on pro-inflammatory factors such as NO, iNOS, TNF-α and IFN-γ in murine macrophage RAW 264.7 cells. NO production and iNOS expression was significantly augmented in LPS treated cell, the production of NO and iNOS was greater in the BRPL than in the PL group. In addition, protein and mRNA levels of TNF-α and IFN-γ in BRPL showed relatively more potent pro-inflammatory-activity inhibition compared to that of PL. These results suggest that BRPL may have significant effects on inflammatory factors, and may be a potential anti-inflammatory therapeutic materials.

우슬(Acyranthes bidentata)은 항관절염(anti-arrthritic), 최음(aphrodisiac), 항바이러스(anti-viral), 항경련(anti-spasmodic), 항고혈압(anti-hypertensive), 항응고(anti-coagulant) 그리고 항암(anti-tumor)효과에 사용되어 왔다. 본 연구는 우슬 추출물로부터 분리한 다당 추출물의 화장품 원료로서의 특성을 알아보기 위하여 항염 효과와 관련된 다양한 실험을 실시하였다. 우슬 다당 추출물을 대상으로 실험한 결과 항염(IL-1α, IL-6, COX-2 그리고 total NO 생성 억제) 효과를 나타내었다.

This research is the basic research to develop new anti-inflammatory medicine by feeding Scutellariae Radix extract to lipopolysaccharide(LPS) exposed rats, and analyzed it's effect on inflammatory response by LPS derivation. As a result, Plasma interleukin-1β(IL-1β) and Plasma interleukin-6(IL-6) concentration showed the highest point at 5h after LPS injection, and in this time, the concentration of IL-1β and IL-6 in the Scutellariae Radix extract groups at 200mg/kg and 300mg/kg showed lower values than that of control group. Plasma tumor necrosis factor-α(TNF-α) concentration after LPS injection showed the highest point at 2h and showed similar level till at 5h. TNF-α concentration at 2h after LPS injection showed the low value only in the Scutellariae Radix extract 300mg/kg group compared to others, and in 5h, the all Scutellariae Radix extract groups showed lower value than that of the control group. Plasma interleukin-10(IL-10) concentration increased at 2h after LPS injection and reached the highest at 5h. After LPS injection the IL-10 concentration at 2h, the Scutellariae Radix extract injection group at 300mg/kg showed higher value than that of the others, and in 5h after LPS injection, Scutellariae Radix extract 200mg and 300mg groups showed higher value than the control group. Concluding from the above results, in inflammatory response by LPS derivation, the Scutellariae Radix gives positive effect.

패장 (Patrinia villosa Jussieu, Valerianaceae)의 뿌리는 한국에서 오래전부터 감염성 질환의 치료에 사용되어왔다. 본 논문에서는 패장근의 물 추출물 엑스 (PVWX)가 proteinase 활성수용체-2 (PAR2)에 의하여 유발된 흰쥐 발바닥 부종에 대한 항염증효과를 연구하였다. 발바닥 부종은 trypsin이나 trans-cinnamoyl-LIGRLO-NH2 (tc-NH2)를 쥐의 발바닥에 주사하여 유발시켰다. PVWX (10, 50, 100 and 200 mg/kg)는 부종유발 1시간 전에 경구로 투여하였다 50, 100 및 200 mg/kg의 PVWX 투여시 부종의 부피와 혈관투과성의 변화에 유의성 있는 억제를 나타냈다. PVWX (100 mg/kg)은 발바닥 조직에서 PAR2 작동약으로 유발된 myeloperoxidase (MPO)활성을 유의성 있게 억제하였다. 이러한 결과들은 PVWX가 PAR2로 유발된 쥐의 발바닥 부종에서 항염증효과가 있음을 보여준다.