The purpose of this study was to evaluate the inhibitory effect of commercial Makgeolli on tumor growth in human gastric adenocarcinoma cells (AGS) in a xenograft cancer model, transplanted with AGS cells. Commercial Makgeolli was first dealcoholized by evaporation and used as the test sample. We detected a significant increase in the volume and weight of tumor in nude mice (induction) that were transplanted with AGS cells. Administration of 100 mg/kg·day group (ML), and 500 mg/kg·day group (MH) dealcoholized commercial Makgeolli significantly decreased tumor growth. In this study, 5-FU 18 mg/kg·day was used as a positive control for tumor growth inhibition. Additionally, determination of the body weight of both the groups revealed no side effects after the administration of dealcoholized commercial Makgeolli. Using the cell culture system, we also evaluated the effect of dealcoholized commercial Makgeolli on caspase-3/7 activity in the AGS cells. Treatment with dealcoholized commercial Makgeolli increased the activation of caspase-3/7 and the apoptotic markers in AGS cells in a dose-dependent manner. Therefore, dealcoholized commercial Makgeolli can be used for cancer prevention.

본 연구에서는 국내 시판되는 비살균 막걸리 8종의 품질 특성을 조사하였다. 막걸리 5종의 알코올 함량은 5.7~5.8%, G , D , C 로 각각 분석되었다. 적정산도는 막걸리 C와 D에서 0.5%이상, H에서는 로 높게 나타났으며, 나머지는 0.45% 이하로 나타났으며, pH는 시료 간에 큰 차이는 없었다. 환원당 함량은 약 200 mg%정도이며, A와 F는 약 90 mg%로 낮게 나타났다. 유기산 중 malic acid는 막걸리 A와 G에서