The recent surge of multijurisdictional IP disputes and increase in non-binding soft laws have made scholars cast doubt on the sustainability of public international law and the validity of the current IP legal system. Private lawyers may now think that they do not have to pay keen attention to public international law any longer when providing legal advice to their clients, particularly MNCs. This study makes a concise description of today’s legal environment in the field of IP, focusing on the emerging legal norms of transnational law, particularly in the context of its interplay with public international law. With respect to this, the ongoing and even heightened roles of public international law will be discussed. Finally, a typology is suggested using exponents to express intensity of State sovereignty to facilitate understanding on the relationship between public international law and other categories of law.

국제해사기구(IMO)의 해상인명안전조약(SOLAS)은 모든 선박이 필수적으로 공인 종이해도, 혹은 전자해도(ENC)를 탑재해야만 한다고 명시하고 있으며, 특히 안전성이 검증된 전자해도 디스플레이 시스템인 ECDIS의 사용을 장려하고 있다. 국제수로기구 내에서는 이러한 ECDIS에 사용되는 공인 전자해도 자료가 지역전자해도 관리센터(RENC)를 통해 보급되어야만 한다는 주장이 커지고 있다. 전 세계적으로 ECDIS의 사용이 일반화되면서, 유럽에 현존하는 두 RENC만으로는 부족하다는 문제점이 제기되었다. 특히, 급격한 경제성장과 더불어 증가하는 아시아 지역의 통항 량은 동아시아 RENC의 필요성을 증명하였다. 본 연구는 2012년에 발효되는 IMO의 ECDIS 강제탑재조건과 현재 RENC의 운영 상황을 바탕으로 RENC 역할의 정의함으로써, 동아시아 수로 위원회의 전략을 참고한 동아시아 지역 독자적 모델(Phase-In)을 통한 RENC 설립의 당위성 및 전략을 연구하였다.

국제해사기구(MO)의 해상인명안전조약(SOLAS)은 모든 선박이 필수적으로 공인 종이해도, 혹은 전자해도(ENC)를 탑재해야만 한다고 명시하고 있으며, 특히 안전성이 검증된 전자해도 디스플레이 시스템인 ECDIS의 사용을 장려하고 있다. 국제수로기구 내에서는 이러한 ECDIS에 사용되는 공인 전자해도 자료가 지역전자해도 관리센터(RENC)를 통해 보급되어야만 한다는 주장이 커지고 있다. 전 세계적으로 ECDIS의 사용이 일반화되면서, 유럽에 현

Wntsignaling is involved in the normal development and tumorigenesis via epithelial- mesenchymal transition (EMT). init iated by down-regul ation of E-cadherin by the transc ription factor Snail. Wnt signaling inhi bits Sna il phosph o rylation t hrough Axin2-dependent pathway that sustains nuclear accumul ation 0 1' Snail by driving CSK3ß nucleocytoplasmic export then consequently increases Snail protein levels and induces an EMT However. the roles of Wnt and Axin expression and their functional implication on Snail dependent EMT program a re not clear du ring the multistep carcinogenic process. We examined that canonical Wnt signaling engagingmul t istep carcinogenic process of uterine cervical cancer through Wnt-Axin2-Snail axis. In nonnal cervi cal mucosa, Wntl. Wnt3a. and Axin2 mRNA expression were locali zed in basal cell layer suggesting that canonical Wnt is required for maintenance of self-renewal program of cervica l epi theli al cells. With progression to cervical int r aepithelial neoplasia (CIN) and carcinoma. Wntl, Wnt3a‘ Axin2, and Snail expression were gradually increased in patient samples suggesting that canonical Wnt pathway is involved in earl y step of carcinogenesis in uterine cervix. LRP6 and Axin2 transfected cells showed the highly increased nuclear Snai l resul ted from dec reased level 0 1' nu clear GSK3ß , indicating that LRP6- Axin2 serves to stabili ze Sna il protein levels and susLains iLs nllclear acc llrnulation by driv ing GSK3ß . RNA interference of Axin2 and Snail on SiHa cells relieved E-cadherin proximal promotel‘ activity and block the in 띠 vo chorioalantoic membra ne ln VaSlOn These results suggest the canon ical Wnt signa ling regul ating Axin2-GSK3ß compartmentalization may important for stabi li zation of E- cad herin repressor Snail during the multistep carcinogen ic process of uteri ne cervix. It may lead to not only tracing the proper biomarker 0 [' ca ncer progression‘ but a lso the development oJ new targets for therapeutic intervention in cancer

The goal of this paper is to examine a rather interesting paradigm involving mixed clausal coordination, where different types of clauses (finite CPs, ECM, and control infinitives) are coordinated. It will be shown that the paradigm in question has consequences for several phenomena; in particular it sheds light on the controversial issue of the proper analysis of PRO as well as the issue of whether the SpecvP where the subject is base-generated is higher or lower than the SpecvP which serves as the landing site of object shift.