The availability and proper use of native plant seeds are essential for effective ecological restoration in the face of rapid climate change. This study established practical seed zones for South Korea to aid in seed collection, management, and production, while also analyzing their current and future climatic characteristics. We delineated 15 seed zones based on administrative boundaries, topographic features, and ecological regions. Using six key bioclimatic variables derived from a 1-km climate dataset (current: 2000- 2019; future: SSP3-7.0, 2041-2060), we conducted evaluations using PERMANOVA and Linear Discriminant Analysis. The analysis revealed significant climatic differentiation among seed zones (R 2=0.6453, p<0.001). Projections indicate that the North Central Hilly (SZ01) and East Central Coastal (SZ11) zones will experience notable qualitative climatic changes, underscoring their susceptibility to climate change. These results serve as a foundation for prioritizing the collection of genetic resources and developing adaptive seed-sourcing strategies. Future work should focus on refining micro-scale seed zones and incorporating species-level genetic information.