Porphyromonas gingivalis is a gram-negative bacteria of rod shape, and grown in an anerobic condition. It colonizes in subgingival crevice and is known as a major pathogen causing chronic periodontitis. It possesses an invasive property and replicative potential within various cell types, presumably playing an important role in modulating biological behaviors of oral cancer. However, the pathophysiology of P. gingivalis in the malignant transformation of oral cancer has not been fully understood. In this study, we aimed to investigate molecular changes of oral squamous cell carcinoma cells induced by repetitive P. gingivalis infection that clinically resembles chronic periodontitis.

• 위신욱(부산대학교 치의학전문대학원 구강병리학교실) | Sin Wook Wi
• 우복희(부산대학교 치의학전문대학원 구강병리학교실) | Bok Hee Woo
• 김다정(부산대학교 치의학전문대학원 구강병리학교실 BK21플러스 사업단) | Da Jeong Kim
• 이지혜(부산대학교 치의학전문대학원 구강병리학교실 BK21플러스 사업단) | Ji Hye Lee
• 박봉수(BK21플러스 사업단 구강해부학교실) | Bong Soo Park
• 박혜련(부산대학교 치의학전문대학원 구강병리학교실 BK21플러스 사업단) | Hae Ryoun Park Correspondence