This study is focused on effects of factors that affect the formation of THMs during chlorination in drinking water treatment. During the chlorination, chlorine consumption is increased by increasing the initial chlorine dose, the pH and the total dissolved solid (TDS) concentration. Also THMs formation is increased up to 58.82 μg/L and 55.54 μg/L by increasing initial chlorine concentration and increasing pH. However, concentration of chloroform is decreased by increasing TDS concentration. This is caused the cation(Na+) of the total dissolved solids preferentially reacts with the functional groups of the organic material which influence the trihalomethane formation. But total trihalomethane formation is increased up to 127.46 μg/L by Br- contained in the total dissolved solids. DOC reduction was not influenced by any of the factors.