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pp.363-371
This study was designed to evaluate the improvement in exercise endurance by Hovenia dulcis fruit hot water extract (HDWE) for the potential application as a functional food material. The effect was based on the evaluation of the forced-swimming capacity and changes in biochemical parameters in mice. Six-week-old mice were classified into four groups based on a randomized block design: the negative control group, the HDWE 50 mg/kg body weight group, the HDWE 200 mg/kg body weight group, and the 1-octacosanol 50 mg/kg body weight group (n=8 mice per group). The swimming exercise time in the HDWE-50 group was increased at 545±43 sec compared to the control group at 263±28 sec. The HDWE-200 fatigue indicators, lactate acid and ammonia content, decreased to 4.99±0.33 mg/mL and 0.63±0.05 mg/mL, respectively. In addition, the content of glycogen in the liver and muscle tended to increase in the group administered HDWE but was not significant. Likewise, the LDH and glucose contents were increased compared to the control group. The muscle damage indicators ALT (52.7±2.6 U/L) and AST (42.5±5.2 U/L) tended to decrease compared to the control group (76.4±10.2 U/L).
서 론
재료 및 방법
1. 헛개나무열매 열수추출물 제조 및 양성 대조군
2. 실험동물 및 시험물질 투여
3. 체중 및 식이 섭취량 측정
4. 강제 수영 시험
5. 채혈 및 조직 적출
6. 혈청 분석
7. 간 및 골격근 내 글리코겐(glycogen) 함량 측정
8. 통계처리
결과 및 고찰
1. 실험동물의 체중과 식이 섭취량에 미치는 영향
2. 간과 골격근 무게에 미치는 영향
3. 강제 수영 시험
4. 혈청 젖산 (lactate) 및 암모니아 (ammonia) 함량에 미치는 영향
5. 간 및 골격근 내 글리코겐 함량에 미치는 영향
6. ALT/AST, CK, creatinine 혈청 지표에 미치는 영향
7. LDH, glucose 혈청 지표에 미치는 영향
요약 및 결론
References
