High concentrations of PM2.5 were generated in new apartments before moving in, and PM2.5 reduction efficiencies using air cleaners and ventilation systems were evaluated. The experimental results for different air cleaner capacities showed that the PM2.5 reduction efficiencies for 46.2 m2, 66 m2, and 105.6 m2 areas were 81.7%, 92.9%, and 92.5%, respectively. Thus, the larger the air cleaning application area, the higher the PM2.5 reduction efficiency. However, there was no difference in the efficiency of overcapacity air cleaners above a certain capacity. The efficiencies of air cleaners located at the living room center, interior wall, and edge were 81.7%, 79.2%, and 75.8%, respectively. There was, therefore, no significant difference in the PM2.5 reduction efficiencies of air cleaners in different locations. Furthermore, the PM2.5 reduction efficiencies at distances of 1 m, 2 m, and 3 m were 81.7%, 81.3%, and 81.7%, respectively. Therefore, there was also no significant difference in efficiency with distance. The PM2.5 concentration decreases rapidly during natural ventilation. Therefore, when the indoor PM2.5 is higher than the outdoor PM2.5, the air cleaner should be used after natural ventilation. The efficiency of PM2.5 reduction using an air supply-type ventilation system in apartments was 35%, which is not high. The simultaneous operation of the ventilation system and kitchen range hood was effective, showing a PM2.5 reduction efficiency of 69.1%. However, a water sprayer was not effective, showing a PM2.5 reduction efficiency of 24.3%. The results of this study suggest that PM2.5 reduction performance should be standardized by evaluating the efficiency of different ventilation systems. Effective usage and maintenance standards for ventilation systems need to be disseminated, and ventilation systems and air cleaners should be used effectively.