Purpose: This study aims to describe the experience of nursing students who used a virtual simulation program for their nursing practicum. Method: Structured debriefing papers were collected from 65 senior nursing students using a convenient sampling method for this qualitative study. Conventional content analysis method was used for data analysis. Results: The study’s findings derived three theme clusters. The theme clusters were “satisfied by leading role in nursing practice and repetitive training,” “gained nursing responsibility and confidence in applying the learning into clinical practice,” and “recognized the limitations of customized nursing care.” Conclusion: The results of this study provided insight into nursing students' virtual simulation-based practical training experiences in the context of the Coronavirus disease-19 (COVID-19) pandemic.