논문 상세보기
pp.179-183
솔잎 열수 증류액에 대한 항산화 활성은 값이 로서 매우 강한 항산화 활성을 나타내었다. 솔잎 열수 증류액에 대한 항돌연변이 활성은 S. typhimurium TA98과 TA100 균주를 이용한 돌연변이성 실험 결과 솔잎 열수 증류액 자체로서는 변이원성이 없었으며 항돌연변이원성 실험에서는 직접변이원인 WNNG 의 경우 S. typhimurium TA100 균주에서 시료농도 에서 의 억제활성을 나타내었으며 4NQO 에 대해서는 동일 농도에서 의
This study was performed to determine the antioxidative, antimutagenic, and anticancer effects of vaporized liquid of water-boiled pine needle(VLP) using DPPH free radical donating method, Ames test, and cytotoxicity. VLP showed the highest electron donating activities . The inhibition rate of VLP in the Salmonella. typhimurium TA100 strain showed inhibition against the mutagenesis induced by MNNG. In addition, the suppression of with same concentration of VLP in the S. typhimurium TA100 strains showed inhibition against 4NQO, respectively. The suppressions under the same condition against Trp-P-1 in the TA98 and TA100 strains were and , respectively. The cytotoxic effects of VLP against the cell lines with human lung carcinoma (A549), human hepatocellular carcinoma (HepG2) , human gastric carcinoma (AGS), human breast adenocarcinoma (MCF-7) and human cervical adenocarcinoma (HeLa) were inhibited with increase of the VLP concentration. The treatment of VLP showed strong cytotoxicities of and against A549, HepG2, AGS, MCF-7 and HeLa, respectively.
