논문 상세보기
pp.749-753
청도반시 추출물로부터 라디칼 소거활성, T-bet promoter 활성, IL-4 발현 활성의 상관관계를 분석하고자 7월부터 10월까지 감을 시기별로 수확하여 분자염증 활성 여부를 확인하였다. 감의 무게는 시기가 경과할수록 무거워지면서 항산화 활성에 있어서는 감이 미숙과일수록 항산화활성이 우수하였다. 4가지의 용매로 추출한 감의 항산화 활성도 유사한 양상을 보였다. T-bet promoter 활성은 추숙이 될 수록 억제되는 양상을 보였는데, 이에
To assess the relationship between anti-oxidant and immunomodulatory activities of Diospyros kaki Thunb. fruit, we harvested persimmons on the first Friday of every month from July to October, and conducted a DPPH assay, a T-bet promoter assay, and an ELISA for IL-4 determination. Anti-oxidant activity increased as fruit weight rose. When the fruit was extracted with five different solvents, and the extracts examined for radical scavenging activity, such activity exhibited a pattern similar to that seen when anti-oxidant activity was assessed. T-bet promoter activity decreased on ripening, whereas IL-4 expression increased, as tested in a DNFB-induced animal model. Collectively, the results suggest that inflammation-inhibitory activity, valuable in treatment of some immune diseases, rises as persimmons ripen.
