Background/Aim: In gallbladder cancer (GBC), gender differences in incidence and mortality rates have been reported with geographic variation. However, there is little known about sex-related difference in GBC prognosis. This study compares prognostic factors according to gender for GBC.
Methods: We searched clinicopathological factors in all stages of 952 GBC patients from seven medical centers in Korea. A total of 927 patients were enrolled and surgery with curative resection was performed in 499 patients.
Results: Carbohydrate antigen (≥37 U/mL) was a significant prognostic factor in both females and males (odd ratio [OR], 4.30; 95% confidence interval [CI], 3.13-5.89; p<0.001). Age was a significant factor only in female patients, elderly patients were associated with low resectability and the likelihood of T-stage >2; an independent predictor of poor prognosis via multivariate analysis (OR, 1.03; 95% CI, 1.01-1.05; p=0.005, OR, 1.05; 95% CI, 1.02-1.08; p=0.002). Body mass index (BMI) also showed gender difference, and lower BMI (≤25 kg/m2) was the significant good indicator of multivariate analysis for lymph node metastasis in female patients (OR, 0.42; 95% CI, 0.23-0.77; p=0.005) but, the significant poor indicator of univariate analysis for advanced T-stage in male (OR, 2.79; 95% CI, 1.40-5.54; p=0.003).
Conclusions: These results suggest that there is a possibility of gender difference in GBC prognosis. Age and high BMI were poor prognostic factors for curative resection for female GBC patients.

INTRODUCTION
METHODS
RESULTS
    1. Baseline characteristics of GBC patients
    2. Predicting factors of unresectability
    3. Pathologic prognostic factors in resectedpatients
DISCUSSION
요 약
ORCID
REFERENCES

• 박양태(고려대학교 의과대학 내과학교실) | Yang Tae Park (Department of Internal Medicine, Korea University College of Medicine, Seoul)
• 강진형(고려대학교 의과대학 내과학교실) | Jinhyong Kang (Department of Internal Medicine, Korea University College of Medicine, Seoul)
• 김재선(고려대학교 의과대학 내과학교실) | Jae Seon Kim (Department of Internal Medicine, Korea University College of Medicine, Seoul)
• 정민규(경북대학교 의과대학 내과학교실) | Min Kyu Jung (Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu)
• 김성훈(전북대학교 의과대학 내과학교실) | Seong Hun Kim (Department of Internal Medicine, Chonbuk National University Medical School, Jeonju)
• 조재희(연세대학교 의과대학 내과학교실) | Jae Hee Cho (Department of Internal Medicine, Yonsei University College of Medicine, Seoul)
• 우상명(국립암센터 간담도췌장암센터) | Sang Myung Woo (Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang)
• 이경주(한림대학교 의과대학 내과학교실) | Kyong Joo Lee (Department of Internal Medicine, Hallym University College of Medicine, Chuncheon)
• 김의주(가천대학교 의과대학 내과학교실) | Eui Joo Kim (Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea) Corresponding author
• 김효정(고려대학교 의과대학 내과학교실) | Hyo Jung Kim (Department of Internal Medicine, Korea University College of Medicine, Seoul) Corresponding author