This study is a descriptive research study attempted to identify factors influencing depression of new nurses, focusing on job stress, self-efficacy, resilience, and social support factors of new nurses. The subjects of this study were 174 new nurses with less than one year of nursing experience, who worked at five university hospitals in the metropolitan area. A self-report questionnaire was used for the data collection of this study. The collected data were subjected to stepwise multiple regression to analyze the factors affecting depression using the SAS 9.4 program. As a result of the study, the average score of depression of the subjects was 13.01 out of 80, Factors influencing the subject's depression were identified including job stress(p<.001), self-efficacy(p=.044), resilience(p=.013), social support(p=.012), work department(p=.021), and work type(p=.001). It was found that the higher the job stress of the subject, the higher the degree of depression, while the higher the self-efficacy, resilience, and social support of the subject, the lower the degree of depression. In this study, it was confirmed that job stress, self-efficacy, resilience, and social support were factors influencing the depression of new nurses. In order to prevent depression of new nurses and actively manage with depression, it is suggested that arbitration programs for new nurses will be needed to reduce job stress of new nurses, strengthen self-efficacy, resilience and social support. It is also thought that strategies supporting for new nurses at the organizational level, such as the establishment of various social support systems, are needed