코로나바이러스병-19(coronavirus disease 2019, COVID-19) 는 위장관 침범을 통해 급성 췌장염을 유발할 수 있으며 바이러스의 췌장 직접 침투 및 사이토카인 폭풍에 의한 간접 손상이 주요 기전으로 제시되고 있다. 기존 연구에 따르면 COVID-19 관련 췌장염은 중증도와 사망률이 더 높고 다른 원인이 명확하지 않은 경우가 많다. 그러나 아직 병태생리와 인과 관계에 대한 연구는 부족하며 향후에 COVID-19와 췌장염의 인과 관계 및 그 임상 양상을 밝히기 위해서는 다른 질환을 최대한 많이 배제하려고 하는 노력이 필요할 것으로 보인다.

Coronavirus disease 2019 (COVID-19) has been linked to various gastrointestinal symptoms, including acute pancreatitis (AP). Emerging evidence suggests that severe acute respiratory syndrome coronavirus 2 may directly and indirectly contribute to pancreatic injury. Additionally, COVID-19-induced systemic inflammation, including cytokine storms, exacerbates pancreatic injury. Clinical studies indicate that COVID- 19-associated AP often presents with severe complications, including necrotizing pancreatitis, higher rates of intensive care unit admission, and increased mortality. However, the clinical characteristics and precise mechanisms remain unclear, partly due to the lack of standardized diagnostic criteria and insufficient research into alternative AP etiologies. Current evidence suggests that COVID-19 may increase the risk and severity of AP, particularly in the absence of traditional causes such as gallstones or alcohol use. Further studies should focus on differential diagnosis and mechanisms of pancreatic injury, contributing to improved recognition and management of AP in the context of the ongoing pandemic.

서 론
본 론
    1. COVID-19에서 급성 췌장염의 발병 기전
    2. COVID-19와 급성 췌장염에 대한 환자 대조군 연구
    3. 국내 보고 현황
    4. 체계적 고찰 및 메타 분석
결 론
요 약
ORCID
REFERENCES

• 황준성(한양대학교 의과대학 창원한마음병원 내과) | Jun Seong Hwang (Department of Internal Medicine, Changwon Hanmaeum Hospital, Hanyang University College of Medicine, Changwon)
• 고성우(가톨릭대학교 의과대학 은평성모병원 내과) | Sung Woo Ko (Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea) Corresponding author