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天花粉水抽出物이 B16 黑色腫細胞의 멜라닌 生成抑制效果

Inhibitory Effect of Aqueous Extract of Radix Trichosanthis on the melanin in B16 Melanoma cells

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  • URLhttps://db.koreascholar.com/Article/Detail/46045
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한국전통의학지 (The Journal of Traditional Korean Medicine)
한국전통의학연구소 (Research Center of Traditional Korean Medicine)
초록

Recently many efforts were focused to understand the mechanical insights of melanogenesis to develop the agents for hyper-pigmentation and hypo-pigmentation. In the melanin biosynthetic pathway, tyrosinase is the rate limiting enzyme, and α-melanocyte stimulating hormone(MSH) stimulate melanogenesis and enhance the melanin synthesis and the tyrosinase activity. This study the effects of Radix Trichosanthis on the basal melanogenic activities of B16/F10 mouse melanoma cells, and on the α-MSH induced melanogenesis. Radix Trichosanthis alone markedly suppressed melanin content and tyrosinase activity in a dose-dependent manner. Pretreatment of the cells with Radix Trichosanthis also suppressed the increase of α-MSH (10 nM) induced melanin content and tyrosinase activity. These results suggest that Radix Trichosanthis inhibits melanogenesis and abrogates α-MSH induced melanogenesis in B16 melanoma cells.

저자
  • 禹元洪(圓光大學校韓醫學專門大學院新藥開發學科) | 우원홍
  • 林圭庠(第三醫學科) | 임규상
  • 李寬順(第三醫學科) | 이관순
  • 宋埰石(第三醫學科) | 송채석
  • 任淑廷(圓光大學校韓醫學專門大學院新藥開發學科) | 임숙정
  • 李成願(圓光大學校韓醫學專門大學院新藥開發學科) | 이성원
  • 文蓮子(圓光大學校韓醫學專門大學院新藥開發學科) | 문연자