Bentonite, which mostly consists of montmorillonite, is considered as a suitable buffer material for disposal of high-level radioactive wastes in deep geological repository due to its high swelling capacity, low permeability, and strong retention capacity of radionuclide migration. Alkaline and saline solutions originated from degradation of cementitious material and seawater intrusion, respectively, may cause the changes in mineralogical and chemical properties of montmorillonite with various processes such as cation exchange within the interlayer, dissolution of montmorillonite, and precipitation of second minerals. In this study, montmorillonite alteration under alkaline and saline environments and its influences on retention of cesium and iodide by bentonite buffer were investigated. The reactions of bentonite (Bentonil-WRK) with alkaline solutions (0.1 M KOH and NaOH) and simulated saline solution were performed for 7 days in batch experiments at 25°C. After the experiments, reacted bentonite samples were characterized by X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) spectroscopy, Short Wavelength Infrared (SWIR) spectrometry. The concentrations of cesium and iodide dissolved in the solutions were analyzed using an inductively coupled plasma mass spectrometer (ICP–MS). The XRD patterns showed significant decrease in the interlayer space of montmorillonite after the reaction with alkaline solution due to cation exchange and change in hydration status at the interlayer. The retention of cesium and iodide in alkaline and saline solutions were affected by montmorillonite alteration and ion competition. Therefore, the montmorillonite alteration affecting the nuclide retention capacity and long-term stability of bentonite buffer should be considered in the safety assessment of long-term geological disposal performance.

The nuclide management technology for separating high-heat generating/high-mobility/long-lived nuclides from high-level wastes based on the chemical reactions is under development. In order to secure the reliability of nuclear non-proliferation and to implement the effective safeguards, it is necessary to consider the safeguards from the conceptual design phase of the novel technologies. However, there was no experience and research on safeguards for the chemical reaction based nuclide management technology. In order to development the available monitoring techniques for the safeguards of nuclide management technology, the possible diversion scenarios were developed and the material flows of major nuclear materials were analyzed according to the various diversion strategies for each unit process in this study. The diversion strategies in this study is limited to the diversion of nuclear materials according to the change of operational parameters (temperature, chemical reagents, pressures, etc). The nuclear material distribution behaviors under the abnormal conditions were analyzed and compared with normal conditions using the HSC Chemistry. The results will be used to determine the proper signals and feasible techniques to monitor the abnormal operations.

Since the National Research and Development Innovation Act. was enacted, evaluation and management of research outputs become more important. The research output is defined as all types of information resources produced from the scientific research activities in each research phase, such as learning, proposing, performing, and publishing. Among them, research outputs mainly from the publishing phase have been systematically managed, including articles, books, technical reports, patents, and software. KINAC, like other Korean R&D institutions, has also achieved growth in research outputs, through continuously increased investment in R&D projects. However, R&D productivity, technology transfer, and commercialization remain low level. The importance of R&D performance diffusion has been emphasized. It’s because the creation of economic value through the utilization of research results has been emerging as a key issue in R&D policy. Therefore, various policies are being nationally pursued to promote the utilization of research achievements, but the results are not being effectively utilized and disseminated. In the field of nuclear nonproliferation and security, it is also difficult to diffuse the R&D performance. In this study, the research outputs of KINAC from 2010 to 2021 were analyzed. A number of research outputs have been made and managed, but the R&D performances have not been analyzed and identified yet. In addition, supportive methods were suggested for efficient performance management toward diffusion. For this purpose, some policies of Korea and other countries concerning performance diffusion -related policies were reviewed. The best practices of performance management and applications were also reviewed and compared to the KINAC cases. As a result, the number of research output has dramatically increased during the last 10 years, showing an average annual total output of 84 and year-on-year increase of 18%. The biggest change was in the conference papers and journals, whereas, there were no trends by year in the case of the technical reports and patents. Of course, it was proportional to the size of the organization, the number of research projects, and its budget. Because many studies highlight the importance of institutional resources, capabilities, and processes for performance management as factors affecting efficient diffusion, the current status of our process was also identified. This study is expected to be applied to the improvement of the performance management of the institute, leading to the enhancement of the R&D performance application.

The measurement activities to evaluate material balance of nuclear material are usually performed by operator. It is because that the IAEA does not have enough manpower to carry out nuclear measurement accountancy of all nuclear materials in the world. Therefore, the IAEA should consider scenarios which facility operator tries to divert nuclear material for misuse by distorting measurement record. It is required to verify the operator’s measurement data whether it is normal or not. IAEA measures inventory items using their own equipment which is independent of facility operator equipment for verification. Since all inventory lists cannot be verified due to limited resources, the number of items to be verified is determined through statistical method which is called as sample size calculation. They measure for the selected items using their own equipment and compares with operator’s record. The IAEA determines sample size by comprehensively considering targeted diverted nuclear material amount and targeted non-detection probability and performance of measurement equipment. In general, the targeted diverted nuclear material amount is considered significant quantity (plutonium: 8 kg, uranium-235: 75 kg). If the targeted non-detection probability or the performance of the verification equipment is low, the sample size increases, and on the contrary, in the case of high non-detection probability or good performance of verification equipment, even a small sample size is satisfied. It cannot be determined from a single sample size calculation because there are so many sample size combinations for each verification equipment and there are many diversion scenarios to be considered. So, IAEA estimates initial sample size based on statistical method to reduce calculation load. And then they calculate non-detection probability for a combination of initial sample size. Through the iteration calculation, the sample size that satisfies the closest to the target value is derived. The sample size calculation code has been developed to review IAEA’s calculation method. The main difference is that IAEA calculates sample size based on approximate equation, while in this study, sample size is calculated by exact equation. The benchmarking study was performed on reference materials. The data obtained by the code show similar results to the reference materials within an acceptable range. The calculation method developed in this study will be applied to support IAEA and domestic inspection activities in uranium fuel fabrication facility.

Avian colibacillosis is severe respiratory and systemic disease caused by avian pathogenic E. coli (APEC). The disease results in economic loss because of early mortality and reduced productivity in chickens. Several antimicrobials have been used extensively for reducing the losses due to colibacillosis. β-lactams, including penicillin derivatives, cephalosporins, and carbapenems, are one of the most commonly used, clinically important antibiotics. In this study, the phenotypic and genotypic characteristics of 14 CTX-M-producing APEC were investigated. Two types of CTX-M genes were detected, namely, CTX-M-1 gene (8 isolates) and CTX-M-15 gene (6 isolates), and all CTX-M-producing APEC were multidrug resistant. Moreover, 10 of the 14 CTX-M-producing E. coli isolates carried the TEM-1 gene, and 8 of the 14 isolates contained class 1 integrons. The following three different gene cassette arrangements were identified in six isolates: aadA1 (n=2), dfrA1 (n=2), and aadA1+dfrA1 (n=2). All CTX-M-producing APEC isolates harbored IncF plasmids, including F, FII, FIA, and FIB. CTX-M-1 gene was located on I1, F, and FIB, and CTX-M-15 gene on FII, FIA, and FIB. The findings from this study indicate that E. coli carrying CTX-M gene are circulating in the broiler poultry industry. Comprehensive surveillance and persistent monitoring of the integrated broiler operations are warranted to prevent the dissemination of resistant isolates.

This investigation aimed to assess the appetite response changes of olive flounder to starving and re-feeding conditions. Three different feeding groups (2 weeks feeding, fed; 2 weeks starving, starved; and 1 week starving and 1 week feeding, re-fed) were established to examine the changes in appetite-related genes for each group. The weight gain of the fish was highest for the fed group and lowest for the starving group. Based on the daily feed intake (DFI) and cumulative feed intake (CFI), overall food intake was found to increase in the re-fed group more than in the fed group from week 1 to week 2 of the experiment. Hypocretin neuropeptide precursor (HCRT) and galanin receptor 1 (GAL-R1) mRNA expression in the brain of olive flounder were decreased in the starved group. Corticotropin-releasing hormone (CRH) was decreased in all experimental groups, except for the fed group. However, overall leptin concentrations in the plasma did not change across groups. Considering the differences between this study and previous studies on starving and feeding, various factors (except the production and expression mechanisms of appetite-related factors in response to starving) are likely acting on the appetite responses of the fish. In this study, a 1-week re-feeding period induced substantial effects on appetite response when compared to a 2-week feeding period. These findings show that even if re-feeding is performed after starving, the unbalance caused by the re-feeding can affect various physiological changes in fish by feed intake efficiency.

Background: Although various conventional approaches have been employed to reduce spasticity in neurological rehabilitation, only a few studies have shown scientific evidence for its effectiveness. Thus, we introduced a different concept (Ueda method) of rehabilitation therapy that can complement the limitations of conventional therapy. Objects: This study aimed to investigate the immediate effects of the application of the Ueda method on patients with spasticity after stroke via an electrophysiological study. Methods: We conducted a randomized double-blind pilot study in two rehabilitation hospitals involving 30 stroke patients who were randomly allocated to the Ueda (n = 15) and convention (n = 15) groups. Electromyographic data of six examined muscles in both upper extremities of all patients were recorded. The A-ApA index and activation ratios of upper extremity muscles were evaluated and compared between the groups to confirm post-intervention changes in upper-extremity flexor spasticity and flexion synergies. Repeated-measures analysis of variance was conducted to confirm the therapeutic effect (2 × 2) as a function of group (Ueda vs. convention) and time (pre-/post-intervention) on all outcome measures (p < 0.05). Results: In the Ueda group, the mean A-ApA index values differed significantly before and after the intervention (p = 0.041), indicating a weak evidence level; however, the effect size was medium (d = –0.503). The interaction effects of the A-ApA index between the Ueda and convention groups and between pre-intervention and post-intervention stages were significant (p = 0.012). The effect size was large (np 2 = 0.220). In the Ueda group, the activation ratios of the anterior deltoid fiber significantly decreased after the intervention in all reaching tasks. Conclusion: The Ueda method reduces upper-extremity flexor spasticity and changes its synergy in stroke patients and should be considered a rehabilitation therapy for spastic stroke patients.