Stent thrombosis (ST) is the sudden occlusion of a stented coronary artery because of thrombus formation. ST is a rare, but can result in life-threatening complications. Early stent thrombosis occurs frequently after primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI). Here, we report a case of a 59-year-old man with acute stent thrombosis immediately after primary PCI with drug-eluting stent for acute STEMI.