This study was designed to investigate the location of Sin-Guel(CV8, 神闕) through literature research. We extracted the part about the location of Sin-Guel(CV8, 神闕) from ancient and modern oriental medical literature which were used commonly in clinic. The results were summarized as follows; 1. The location of Sin-Guel(CV8, 神闕) were generally recorded DangJeJung. 2. Sin-Guel(CV8, 神闕) placed in middle of linea alba. 3. Treatment effect of moxibustion on Sin-Guel(CV8, 神闕) were recorded as diarrhea, dropsy, prolapse of the anus, stomachache, paralysis etc.. 4. Acupuncture therapy on Sin-Guel(CV8, 神闕) is dangerous because of inflammation, it is suggested that acupuncture therapy may be possible if acupuncture therapy do not induce inflammation on Sin-Guel(CV8, 神闕).