The film with methylcellulose(MC) and grape seed extract(GSE) were prepared by casting their aqueous solution at 80oC and dryng at 23oC for 48 hrs. Effect of grape seed extract (GSE) on the barrier permeabilities and the thermomechanical property of methylcellulose(MC) film was studied. The barrier permeabilities and the thermomechanical property of MC films containing various contents of GSE were evaluated in terms of water vapor, oxygen permeabilities, and dynamic mechanical analysis(DMA). The rate of water vapor permeability of MC films decreased with GSE contents in the MC films. Also, the rate of oxygen permeability also decreased with GSE contents indicating higher oxygen barrier property of the MC film. The results showed that GSE had a good miscibility with MC and acted as a plasticizer for MC films resuling in lowering the glass transition temperature of the film.