목적 : 본 연구는 일상생활에서 범하기 쉬운 사소한 실수들의 빈도를 통해 인지적 손상정도를 평가하는 인지적 실패 질문지Cognitive Failure Questionnaire(CFQ)의 국내 적용을 위한 번역연구 및 번역된 설문지의 신뢰도를 알아보고자 하였다. 연구방법 : 본 번역 과정은 총 5단계로 진행되었다. 첫 번째 과정에서 작업치료사 1명이 인지적 실패 질문지 25개 항목을 한국어로 번역하였고, 두 번째 과정으로 재활전문가 으로 구성된 번역 검증 위원회에서 한글번역의 적합성 검증을 실시하여 부적절한 항목을 수정하였다. 세 번째 과정은 9명의 인지기능 장애가 있는 환자들을 대상으로 설문항목에 대한 이해도를 10점 척도로 조사하였고, 이해도가 낮은 항목들은 다시 번역검증위원회를 통해 수정하였다. 수정된 질문지는 번역 전문가를 통해 역번역하였고, 마지막으로 영어를 모국어로 하는 외국인 2명이 원문과 역번역본의 문장구조 및 의미전달의 유사성을 검증하였다. 최종 번역된 질문지는 15명의 인지기능 장애가 있는 환자군에게 1-2주일 간격으로 실시하였고, 검사·재검사 신뢰도는 급간 내 상관계수로, 내적 일치도는 크롬바 알파(Cronbach α)로 분석하였다. 결과 : 한글 번역 적합성 검증 결과 총 11개 항목을 수정하였으며, 수정된 질문지에 대한 이해도 평가 결과 대부분 의 항목에서 높은 이해도를 보였다(평균 9.0-10.0). 또한 역번역 검증 과정을 통하여 총 3개 항목을 수정하였다. 최종 번역본에 대한 검사·재검사 신뢰도는 ICC .807, 내적 일치도는 Cronbach a= .878로 나타났다. 결론 : 본 연구는 체계적인 번역 과정을 통하여 국내 적용을 위한 설문내용의 적합성과 이해도를 높였다. 또한 신뢰도 검증을 통하여 추후 인지기능 장애가 있는 뇌손상 환자군에서 인지적 실패 질문지가 다양하게 사용될 수 있는 기반을 마련하였다.

Bone morphogenetic proteins (BMPs) are known to promote osteogenesis, and clinical trials are currently underway evaluating the ability of BMPs to promote bone formation in grafting procedures and fracture healing. Some studies, have independently reported that sulfated polysaccharides particularly heparin, enhance the osteoblastic differentiation induced by BMPs in vitro, and another study demonstrated that heparin enhanced the bone formation induced by BMP‐2 in vivo. This study was performed to examine adipose stem cell responses to rhBMP‐2 alone and rhBMP‐2 with heparin at 0.25, and 25 μg/㎖ concentrations, respectively, in culture media. Adipose stem cells were cultured for 2, 4, and 8 days toward the osteoblastic differentiation in rhBMP‐2 alone and rhBMP‐2 with heparin at 0.25, and 25 μg/㎖ concentrations, respectively, in culture media. Verification of the stem cell lineage was performed in two ways. The first method was a continuous sequential culture until 5th generation. The second method was using monoclonal antibodies for STRO‐1 and CD 90. Naphthol AS phosphate‐fast blue BB staining for alkaline phosphatase was used for verifying osteoblastic differentiation because Alkaline phosphatase activity had been used as an osteoblastic differentiation marker and degree of osteoblastic activity. Alizarin red staining was also used as an osteoblastic differentiation marker because it quantifies the calcium levels in cells or tissues. During the 5th generation culture, cultured cells actively proliferated, and these cultured cells showed a positive reaction to STRO‐1 and CD90 cell surface molecules. Naphthol AS phosphate‐fast blue BB staining and Alizarin red staining were positive in most samples of each group at 2, and 4 days and positive reaction was proportioned to degree of morphological differentiation. In the concentration of 25 μg/ml of heparin, the ALP activity was highest at the 2nd day in the culture, and then the activities of ALP were decreased significantly at 4, and 8 days. The ALP activity was greatest at the 4th day of the culture, and then decreased significantly at the 8th day in 0 μ g/ml and 0.25 μg/ml of heparin concentrations, Adipose stem cells could be differentiated in rhBMP‐2 in culture media, and the addition of heparin to BMP‐2 promoted differentiation of osteoblasts. Moreover, morphological differentiation was associated with the activity of osteoblasts. This study was shown that, when heparin concentration increases, the early differentiation of the cells was brought about, but the early differentiated cells were rapidly progressed to degenerative changes

Currently, the Korea Atomic Energy Research Institute (KAERI) is planning to build the Ki-Jang Research Reactor (KJRR) in Ki-Jang, Busan. It is important to safely dispose of low-level radioactive waste from the operation of the reactor. The most efficient way to treat radioactive waste is cement solidification. For a radioactive waste disposal facility, cement solidification is performed based on specific waste acceptance criteria such as compressive strength, free-standing water, immersion and leaching tests. Above all, the leaching test is important to final disposal. The leakage of radioactive waste such as 137Cs causes not only regional problems but also serious global ones. The cement solidification method is simple, and cheaper than other solidification methods, but has a lower leaching resistance. Thus, this study was focused on the development of cement solidification for an enhancement of cesium leaching resistance. We used Zeolite and Loess to improve the cesium leaching resistance of KJRR cement solidification containing simulated KJRR liquid waste. Based on an SEM-EDS spectrum analysis, we confirmed that Zeolite and Loess successfully isolated KJRR cement solidification. A leaching test was carried out according to the ANS 16.1 test method. The ANS 16.1 test is performed to analyze cesium ion concentration in leachate of KJRR cement for 90 days. Thus, a leaching test was carried out using simulated KJRR liquid waste containing 3000 mg·L-1 of cesium for 90 days. KJRR cement solidification with Zeolite and Loess led to cesium leaching resistance values that were 27.90% and 21.08% higher than the control values. In addition, in several tests such as free-standing water, compressive strength, immersion, and leaching tests, all KJRR cement solidification met the waste acceptance or satisfied the waste acceptance criteria for final disposal.

About 4,800 soil drums were generated in the process of maintenance on KRR site (Korea Research Reactor) in Seoul. Most of the drums are processed by regulatory clearance in 2007-2008 and the remaining 1800 drums are currently stored in KAERI (Korea Atomic Energy Research Institute). To decide a treatment method of radioactive soil for final disposal, the soil is classified according to a particle size. Based on the results of the radioactivity concentration for the classified soil, methods such as regulatory clearance, decommissioning, and solidification were decided. Many papers show that radioactive soil is disposed of using a decontamination agent or other method. But it is difficult to decontaminate radioactive particles from fine soil particles because the adsorptive power of fine soil particles is too strong. This study was focused on finding a particle size distribution of radioactive soil that can be used as an operating range for cement solidification produced by a suitable ratio of radioactive soil for final disposal. Workability, free-standing water, compressive strength, immersion, and leaching tests were carried out to evaluate characteristics of the cement solidification. Cement solidification is the only method for final disposal because radioactive soil particle sizes below 500 μm exceed the regulatory clearance criteria (< 0.1 Bq/g). According to the test results for cement solidification, 0.4 water/cement and 0.5 soil/cement ratios are the most appropriate operating ranges.