This study was conducted to find material having antibacterial activity. The effects of preservatives, antibiotics and oriental medicines on growth of tested microorganisms were investigated. The growth of all tested bacteria was inhibited by water extract of Schizandra chinensis. Antibacterial activity on the concentration of Schizandra chinensis extract was tested. The growth of Escherichia coli W3110, Enterobacter cloacae MG82 and Salmonella typhimurium was extraordinarily inhibited by more than 0.2% concentration of Schizandra chinensis extract. The specific growth rate of Escherichia coli W3110, Enterobacter cloacae MG82 and Salmonella typhimurium under control condition had mean values of 0.514(hr-), 0.381(hr-) and 0.489(hr-), respectively. When 0.2% of Schizandra chinensis extract was added, specific growth rates of Escherichia coli W3110, Enterobacter cloacae MG82 and Salmonella typhimurium were decreased, compared to control, in 1.26, 2.23 and 1.50 fold, respectively. Minimal inhibitory concentration of Schizandra chinensis extract was 0.25% on the tested microorganisms. The growth of Enterobacter cloacae MG82 was more inhibited by Schizandra chinensis extract than other tested microorganisms.