The abnormal meat could caused by abscess, fibrosis and granuloma in the region of the neck by the adverse effect of foot-and-mouth disease (FMD) vaccination practice for Korean swine. After FMD vaccination was implemented in 2010, the number of incidences of abnormal meat has been increasing. In this study, it was evaluated whether needless intradermal injection (NII) of FMD vaccine reduces abnormal meat at the injection site in comparison to conventional intramuscular injection (IM). In addition, the onset of humoral immunity was analyzed in order to see if NII of this vaccine is able to mount comparable antibody response with IM. This study was carried out in four Korean pig farms. The O-type FMD vaccine was implemented via NII at three farms and the control group was vaccinated via IM. Antibody titers were compared from the serum samples taken from 10 random pigs at age of 8, 12, 16 and 22~24 weeks of age. The O+A type FMD vaccine was also compared with the same protocol. When test animals were slaughtered, incidence, type and size of abnormal meat were recorded. The results of this study showed that the antibody titers between intradermal and intramuscular group were similar but a significant difference in the incidence of abnormal meat formation was observed between two groups (p < 0.05). In summary, needless intradermal injection of FMD vaccination was proven to be effective for the onset of humoral immunity and reducing abnormal meat formation.

본 연구에서는 만성질환의 주요 위험인자인 비만을 예방 하기 위한 식품소재로서 3T3-L1세포를 이용하여 탈피한 도 토리의 항비만 효과를 알아보고자 하였다. 3T3-L1 세포에서 생존율(MTT assay)을 측정한 결과, AE와 AW 시료 모두 500 μg/mL 농도에서는 다소 생존율의 감소를 보여, 300 μg/mL를 최종 농도로 정하였다. 3T3-L1 세포의 지질축적 억제 효과를 측정한 결과, 농도 100 μg/mL로 처리하였을 때 두 시료 모두 지질축적량의 증가를 보였으나, 200 μg/mL 처리농도에서 AE 시료는 82%로, AW 시료는 74%로 감소되다가 300 μg/mL 농 도에서는 두 시료 모두 약 53% 수준까지 지질축적이 억제되 었다. 3T3-L1 세포에서 중성지방 억제 효과를 확인한 결과, AE 시료의 경우 200 μg/mL 농도에서 11%의 감소율, 300 μg/mL 농도에서 42% 수준의 감소율을 보였다. AW 시료도 200 μg/ mL 농도에서 5%의 감소율과 300 μg/mL에서 41%의 감소율 을 보였다. 3T3-L1 세포의 ROS 생성량을 측정한 결과, 시료 농도 200 μg/mL에서 AE는 42%, AW는 33%로 300 μg/mL에 서는 AE는 58%, AW는 52%로 ROS 생성량의 억제를 보였다. 3T3-L1 세포에서 mRNA 발현에 미치는 영향을 대조군과 비 교하였을 때 두 시료(AE와 AW) 모두 300 μg/mL 농도에서 PPAR-γ은 54%와 38%, aP2는 40%와 18% 수준의 발현을 억 제시키는 것으로 나타났다. 이상의 결과로 볼 때 탈피한 도토 리는 3T3-L1 세포의 분화를 억제함으로써 새로운 항비만 소 재로의 가능성이 있는 것으로 판단된다.

We present the results of a highly sensitive (~10 mK rms) survey toward the central parts of 22 barred spiral galaxies in 12CO(1-0) line using the NRAO 12m telescope at Kitt Peak. Seven of the target galaxies were detected in CO; NGC 3686 has been detected with CO for the first time. We estimated central CO fluxes of 50~1000 Jy km s-1 and molecular gas masses of 107~108 M⊙ for those galaxies.

We present results of a H13CN J=1-0 mapping survey of molecular clouds toward the Galactic Center (GC) region of -1.6° ≤ l ≤ 2° and -0.23° ≤ b ≤ 0.30° with 2' grid resolution. The H13CN emissions show similar distribution and velocity structures to those of the H12CN emissions, but are found to better trace the feature saturated with H12CN (1-0). The bright components among multi-components of H12CN line profiles usually appear in the H13CN line while most of the dynamically forbidden, weak H12CN components are seldom detected in the H13CN line. We also present results of other complementary observations in 12CO (J=1-0) and 13CO (J=1-0) lines to estimate physical quantities of the GC clouds, such as fractional abundance of HCN isotopes and mass of the GC cloud complexes. We confirm that the GC has very rich chemistry. The overall fractional abundance of H12CN and H13CN relative to H2 in the GC region is found to be significantly higher than those of any other regions, such as star forming region and dark cloud. Especially cloud complexes nearer to the GC tend to have various higher abundance of HCN. Total mass of the HCN molecular clouds within |l|≤ 6° is estimated to be ~2 ×10 7 M⊙ using the abundances of HCN isotopes, which is fairly consistent with previous other estimates. Masses of four main complexes in the GC range from a few 10 5 to ~ 10 7 M⊙ All the HCN spectra with multi-components for the four main cloud complexes were investigated to compare the line widths of the complexes. The largest mode (45 km s-1) of the FWHM distributions among the complexes is in the Clump 2. The value of the mode tends to be smaller at the farther complexes from the GC.

The oriental ore minerals, which mainly consisted of talc, actinolite, sericite, and halloysite were developed, and then used to examine the healing effect on the skin wound in rats. Full-thickness square wounds were formed on the backs of rats after the hairs on the dorsal surface were shaved. The ore minerals were applied to examine the healing effect from day 0 to 15 after wounding. Notable wound healings in terms of congestion around the wound, wound contraction and epithelialization were found in ore mineral-treated groups. Moreover, microscopic results revealed the formation of epithelial layer, hair follicles and progressive angiogenesis in ore mineral-treated groups, while complete epithelial layer could not be found in the control. These results suggest that ore minerals from Korean indigenous ores may have wound healing effect on the skin injury in rats.