The levonorgestrel-releasing intrauterine system (LNG-IUS) is used for contraception and treatment of heavy menstrual bleeding as well as endometrial hyperplasia and early endometrial carcinoma. A 48-year-old woman visited an Internal Medicine outpatient clinic due to significantly elevated CA-125 and CA-19-9 levels in a routine health examination. She had been using LNG-IUS for 3 years. Before LNG-IUS insertion, she suffered from heavy menstrual bleeding and severe dysmenorrhea. Her endometrial sampling and ultrasonographic imaging showed no evidence of endometrial carcinoma at the time of LNS-IUS insertion. After insertion, she complained of neither abnormal uterine bleeding nor dysmenorrhea. She received a routine health check-up every year and showed results within normal range until last year. To rule out pancreatic cancer due to significantly elevated CA-19-9 levels, her physician performed positron emission tomography–computed tomography, which demonstrated increased FDG uptake in the endometrial cavity. We obtained endometrial biopsy and found endometrial carcinoma in her uterus and performed radical hysterectomy with bilteral pelvic lymphadectomy. Permanent pathology confirmed endometrial carcinoma with lymph node metastasis. She received concurrent chemoradiation therapy. We emphasize the necessity of regular follow-ups with ultrasonography and assessment of serum tumor markers for the early detection of endometrial carcinoma, although rare, in women using LNG-IUS, including those without abnormal uterine bleeding.

To investigate the association between maternal iron status at the third trimester and fetal birthweight, maternal serum iron, ferritin, total iron-binding capacity (TIBC), and complete blood count values were measured at 36-weeks gestation. Delivery database on mothers who delivered babies at Chungbuk National University Hospital between January 2008 and March 2013 was extracted. A total of 353 uncomplicated term babies were analyzed using hierarchical regression and ANCOVA. Maternal age (standardized regression coefficient β=0.115, P<0.05), height (β=0.108, P<0.05), BMI (β=0.210, P<0.001), and gestational age (β=0.298, P<0.001) were significantly associated with birthweight. However, birthweight was not associated with maternal iron parameters. After adjusting for maternal age, height, BMI, and gestational age, babies born to mothers with lower mean values of hemoglobin, hematocrit, and serum ferritin were heavier than those born to mothers with higher values. Babies born to lower hemoglobin (11 g/dL) mothers were heavier than those born to higher hemoglobin (12 g/dL) mothers. However, birthweight was not significantly different between mothers with 10 g/dL or 13 g/dL of hemoglobin. Comparing birthweight according to 30 ug/dL of serum iron, 360 ug/dL of TIBC, 15 ng/mL of serum ferritin, and 10% transferrin saturation, babies born to mothers of the lower group were heavier than those born to mothers of the higher group. Therefore, maternal serum iron status at the third trimester seems to not be associated with birthweight.

본 연구는 삼채뿌리분말을 첨가하여 김치의 맛과 저장성 을 증진시키는 김치를 개발하고자 품질특성을 관찰하였다. 삼채뿌리분말 0.1%, 1%, 5%를 첨가하여 4℃에서 8주 동안 저장하였으며 저장기간에 따른 pH, 산도, 염도, 환원당, 미 생물의 변화 및 관능특성을 살펴보았다. 삼채뿌리의 비타 민 B1및 비타민 C의 함량은 각각 0.04 mg/100 g 및 5.76 mg/100 g으로 나타났으며, 삼채 뿌리의 비타민 B1의 함량은 마늘보다는 적고 양파와 비슷한 수준으로 검출되었다. 삼 채뿌리분말 첨가 김치의 pH의 측정결과 초기의 pH는 비슷 하였으나, 저장기간 중 삼채뿌리분말을 첨가하지 않은 일 반김치는 삼채뿌리분말을 첨가한 김치에 비하여 대체적으 로 낮은 pH를 보였으며, 삼채뿌리분말 5% 첨가한 김치의 pH가 가장 높게 나타났다. 산도의 측정결과 pH 변화와 비슷 하였으며, 삼채뿌리분말첨가 김치의 염도는 대체로 2.23% 를 유지하였다. 환원당 함량의 측정 결과 삼채뿌리분말 0.1%, 1%, 5% 첨가 김치는 발효가 진행됨에 따라 모든 군에서 환원당 함량이 지속적으로 감소되었고, 삼채뿌리분 말 첨가량이 많을수록 환원당 함량이 높은 것을 알 수 있었 다. 숙성 중 총 균수 및 젖산균수 변화는 숙성 초기에 급격히 증가한 후 서서히 증가하는 경향을 보였다. 관능적 특성을 살펴보면 외관, 맛, 전반적인 기호도 에서 삼채뿌리분말 1% 첨가 김치의 평가가 가장 우수하였다. 이상의 결과를 보면 삼채뿌리분말을 첨가한 김치의 pH가 높고 천천히 감 소되는 점으로 미루어 볼 때, 숙성 지연 등의 저장성과 기호 성이 좋은 삼채뿌리분말 1%를 첨가하여 김치를 개발하는 것이 적합한 것으로 사료된다.