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        검색결과 3

        1.
        2018.11 구독 인증기관·개인회원 무료
        Recent transcriptome analyses have shown that long non-coding RNAs (ncRNAs) play prevalent roles in transcriptional regulation. We have reported that promoter-associated ncRNAs (pancRNAs) activate the partner gene expression via local epigenetic changes. Here, we identify thousands of genes under the pancRNA-mediated transcriptional regulation in five mammalian species in common. In the mouse, 1) pancRNA-partnered genes show tissue-specific expression pattern, 2) expression of pancRNAs significantly enriched H3K4me3 and H3K27ac marks towards the partner gene expression, 3) H3K4me1 marks the pancRNA-partnered genes regardless of their expression level, and 4) C- or G-skewed motifs were exclusively overrepresented between -200 and -1 bp relative to the transcription start sites of pancRNA-partnered genes. More importantly, the comparative transcriptome analysis among five different mammalian species using a total of 25 counterpart tissues showed that overall pancRNA expression profile exhibited extremely high species-specificity compared to that of mRNA, suggesting that a significant number of pancRNAs contributed to the enhancement of a set of partner genes' expression in a sequence-specific manner. We conclude that the gain and/or loss of gene-activation-associated pancRNA repertories, caused by formation or disorganization of the genomic GC-skewed structure, finely shapes tissue-specific pattern of gene expression according to a given species.
        2.
        2006.09 구독 인증기관·개인회원 무료
        Sr2Ta2O7, a layered perovskite compound, has been reported to possess most excellent photocatalytic properties among the layered perovskite materials. Recently, we have demonstrated that Ba5Ta4O15 that was prepared under a mol ratio of Ba: Ta=1:1 has high photocatalytic performance as well as Sr2Ta2O7. In this study, the photocatalyst samples with a mol ratio of Sr: Ba: Ta = (1-x): x: 1 were prepared. The maximum photocatalytic performance was obtained for x= 0.2, which is three times as high as that of undoped Sr2Ta2O7.