Sweet potato (Ipomoea batatas L.) is an essential crop in the Paraguayan diet. It plays a crucial role in food security. It is a source of income for family agriculture. It has a significant potential to adapt to various climatic and soil conditions in Paraguay, making it a promising crop for improving productivity. However, Paraguay faces a deficit in the development of sweet potato cultivation technology, resulting in a low productivity of 5.3 ton/ha. Efforts have been made to collect and characterize sweet potato genotypes, covering a diversity of native varieties. These efforts have laid the groundwork for future sweet potato research and development. Still, ongoing research and development of strategies are needed to address existing challenges of improving genetic resource traits and developing cultivation technology and to fully exploit growth opportunities in this sector. This review summarizes sweet potato cultivation in Paraguay, focusing on several key technical aspects. It analyzes current market situation and production conditions as well as the availability of genetic materials adapted to different ecoregions. Additionally, it explores prospects for the development of advanced sweet potato crops, including the production of high-quality, virus-free sweet potato plants with improved productivity.