Periodontal disease is a chronic but treatable condition which often does not cause pain during the initial stages of the illness. Lack of awareness of symptoms can delay initiation of treatment and worsen health. The aim of this study was to develop and compare different risk prediction models for periodontal disease using machine learning algorithms. We obtained information on risk factors for periodontal disease from the Korea National Health and Nutrition Examination Survey (KNHANES) dataset. Principal component analysis and an auto-encoder were used to extract data on risk factors for periodontal disease. A synthetic minority oversampling technique algorithm was used to solve the problem of data imbalance. We used a combination of logistic regression analysis, support vector machine (SVM) learning, random forest, and AdaBoost to classify and compare risk prediction models for periodontal disease. In cases where we used principal component analysis (PCA) to extract risk factors, the recall was higher than the feature selection method in the logistic regression and support-vector machine learning models. AdaBoost’s recall was 0.98, showing the highest performance of both feature selection and PCA. The F1 score showed relatively high performance in Ada- Boost, logistic regression, and SVM learning models. By using the risk factors extracted from the research results and the predictive model based on machine learning, it will be able to help in the prevention and diagnosis of periodontal disease, and it will be used to study the relationship with various diseases related to periodontal disease.

The Port of Pyeong Taek is located on the west coast, meaning that the difference between the rise and fall of tide is great (flood tide 1.8 to 2.9 knots, ebb tide 1.6 to 2.9 knots). Due to mainly N~NW’ly strong winds & high waves during winter, navigating as well as loading & discharging vessels must focus on cargo handling. The strong tidal and wind forces in the Port of Pyeong Taek can push an LNG carrier away from its berth, which will end up causing forced disconnection between the vessel’s cargo line and shore-side loading arm. The primary consequence of this disconnection will be LNG leakage, which will lead to tremendous physical damage to the hull and shore-side equipment. In this study, the 125K LNG Moss Type ship docked at No. 1 Pier of the Pyeong Taek is observed, and the tension of the mooring line during cargo handling is calculated using a combination of wind and waves to determine effective mooring line and mooring line priority management. As a result if the wind direction is 90° to the left and right of the bow, it was found that line monitoring should be performed bearing special attention to the Fore Spring Line, Fore Breast Line, and Aft Spring Line.

Japanese pine sawyer, Monochamus alternatus, is the main pest that mediates pine wilt nematode, Bursaphelenchus xylophilus, that causes serious damage to pine forests. In this study, we studied the strategy to control M. alternatus using entomopathogenic fungi. The fungi were collected from soil by an insect-baiting method and two fungal isolates (Metarhizium anisopliae JEF-197 and JEF-279) showed high virulence against M. alternatus. The Metarhizium isolates were evaluated for insecticidal activity against M. alternatus by spray treatment on live pine trees and wintering trees, and the M. anisopliae JEF-197 showed high insecticidal activity. In addition, the interaction of fungi and M. alternatus were analyzed by RNA-seq. This result can contribute to the development of insect control agents using entomopathogenic fungi.

원전 해체 공정 중 절단 및 용융작업에서 발생되는 방사성 에어로졸은 작업종사자의 호흡을 통해 내부 피폭을 유발하게 된다. 이에 따라 해체 중 방사성 에어로졸로 인한 작업종사자의 내부피폭 평가가 필요한 실정이다. 정확한 내부피폭평가를 위해서는 작업종사자의 작업환경 실측값이 필요하지만 실측에 어려움이 있을 시에는 국제방사선방호위원회(ICRP)에서 제시하는 섭취량 분율 및 입자 크기 등의 권고 값을 통해 내부피폭선량을 추정할 수 있다. 본 논문에서는 입자 크기의 선정은 ICRP에서 권고하는 작업종사자의 고려 입자 크기인 5 μm을 적용하였다. 발생량의 경우, 불가리아의 Kozloduy 부지 내의 용융시설에서 발생 된 에어로졸의 포집량 데이터를 이용하여 섭취량을 산정하였다. 또한 이를 이용해 작업종사자의 체내 및 배설물에서의 방사능 수치를 계산하고 BiDAS 전산코드를 통해 내부피폭 평가를 수행하였다. Type M이 0.0341 mSv, Type S가 0.0909 mSv로 두 흡수 형태 각각 국내 연간 선량 한도의 0.17%, 0.45% 수준을 나타내었다.

Interferon-tau (IFNT) is known as a major conceptus protein that signals the process of maternal recognition of pregnancy in ruminants. Also, multiple interferon genes exist in cattle, However, molecular mechanisms of these bovine IFNT (bIFNT) genes whose expressions are limited have not been characterized. We and others have observed that expression levels of bovine subtype IFNT genes in the tissues of ruminants; thus, bIFNT1 and other new type I (bIFNTc1/c2/c3) gene co-exist during the early stages of conceptus development and non-trophoblast cells. Its genes transcription could be regulated through CDX2 and ETS2 and JUN and/or cAMP-response element binding protein (CREB)-binding protein (CREBBP) expression, a transcription factor implicated in the control of cell differentiation in the trophectoderm. Bovine ear-derived fibroblast cells, were co-transfected with luciferase reporter constructs carrying upstream (positions -1000 to +51) regions of bIFNT1 and other new type I gene and various transcription factor expression plasmids. Compared to each - 1kb-bIFNT1/ c1/c2/c3-Luc increased when this constructs were co-transfected with CDX2, ETS2, JUN and/or CREBBP. Also, Its genes was had very effect on activity by CDX2, either alone or with the other transcription factors, markedly increased luciferase activity. However, the degree of transcriptional activation of the bIFNTc1 gene was not similar to that bIFNT1/c2/c3 gene by expression plasmid. Furthermore, Sequence analyses also revealed that the expression levels of bIFNT1/c2/c3 gene mRNAs expression were highest on day 17, 20 and 22 trophoblast and, Madin-Darby bovine kidney (MDBK), Bovine ear-derived fibroblast (EF), and endometrium (Endo) non-trophoblast cells. But, bIFNTc1 mRNA had not same expression level, bIFNTc1 lowest levels than those of IFNT1/c2/c3 gene in both trophoblast and non-trophoblast cells. These results demonstrate that bovine subtype bIFNT genes display differential, in the trophoblast and non-trophoblast cells.

Variance of conceptus interferon tau (IFNT), produced by the embryonic trophectoderm, is known as a major conceptus protein that signals the process of maternal recognition of pregnancy in ruminants, essential for the maintenance of early pregnancy. Similar to other IFN genes such as IFNA and IFNB, multiple IFNT genes are present. However, some kinds of IFNT genes actively transcribed and regulated in bovine conceptuses have not been well characterized. In this study, during the course of bovine IFNT gene transcription through the use of next generation sequencer SOLiD3, revealed that among 38 IFN genes registered, only two transcripts, IFNT1 and IFNTc1, were found in conceptuses during early pregnancy. Also, to identify a transcription factor(s) involved in the regulation of IFNT genes, mRNAs for various known transcription factors were investigated by real-time PCR in conceptus tissues, respectively. Furthermore, compared to the IFNT genes, IFNT1 and IFNTc1 had same active levels, which were previously shown to correlate with the appearance of effective antiviral activity. However, the expression levels of these Luc activities differed. Bovine ear fibroblast (EF) cells were cotransfected with luciferase reporter constructs carrying upstream (–631 to -51) promoter regions of IFNT1 or IFNTc1 and various transcription factor expression plasmids, CDX2, AP1(JUN), ETS2 and/or cAMP-response element binding protein (CREB)-binding protein (CREBBP). CDX2, either alone with the other 2 transcription factors, was found to increase luciferase activity approximately 14- and 11-folds, respectively. The degree of transcriptional activation of the IFNTc1 gene was not similar to that IFNT1 gene by AP1, ETS2 or/and CREBBP, expression plasmid. These results suggest that two isoforms of bovine conceptus IFNT genes are regulated differently in conceptuses during early pregnancy.

Japanese pine sawyer beetle, Monochamus alternatus Hope (Coleoptera: Cerambycidae) is considered as a serious pest in pine trees. To develop an eco-friendly strategy to manage this forest insect, we collected entomopathogenic fungi from Korean soil and assessed their virulence against the adults of the insect in laboratory conditions. As a result, two isolates with conidial suspension (1.0×107conidia/ml), showed 87% and 90% mortality 12 days after fungal treatment, respectively. We assessed the potential of the fungi-derived destruxin and protease as additives to the fungal isolates, and they showed insecticidal activity via feeding and spraying treatments. Finally, we produced fungal conidia in massive solid cultures and formulated wettable powders, and now studying optimal conditions of oil-based formulation with two isolates. Based on these results, we are evaluating the control efficacy of the fungal agents against M. alternatus in field conditions.

Modern manufacturing industries is to produce both precise and robust mechanical parts without failure while they are in service. In order to prevent a part failure for its lifetime, a mechanical design for a part should be examined on a basis of mechanical simulation. A nozzle plate, being a key part in steam engines, changes flow directions of steam in a turbine used in power plant. This paper is to the design and test for part safety and durability. Currently, nozzle plates are fabricated by welding nozzles to their plates. Welding causes some defects on the used materials while they are being manufactured. Another major defect is un-even pitches between welded nozzles. Welding causes phase changes because of high melting temperature of metal. This leads to decay on the welding spots, which weakens their structural strength and then, may lead to early damages on mechanical structures. This research proposes assembly-typed nozzle plate without welding. From the beginning, nozzle and plate are designed for insertion-typed assembly. Nozzle head and foot are designed in accordance with the grooves on outer ring and inner ring of a plate to make mating surfaces. Then the nozzle plate should be proved for structural and fatigue safety before they are put in manufacturing. This research adopts commercial softwares for modeling and mechanical simulation. The test result shows that the design with smaller mating area and deeper insertion produces higher safety in terms of structure and durability. From the conclusion, this paper proposes the assembly-typed nozzle plate to replace the welding typed.

Japanese pine sawyer, Monochamus alternatus Hope (Coleoptera: Cerambycidae) in forest is considered as a serious forest pest in pine trees. In this study, we collected entomopathogenic fungi from soil and assessed their virulence against the adults of the inset using a spray method in laboratory condition. Two entomopathogeinc fungi isolates showed high virulence against the adults. In the concentration of 1.0 × 107conidia/ml, the mortality rate of the adults were 53% and 60%. In semi-field condition, one isolate showed a virulence of 60% against the adult. Consequently, we confirmed the possibility of the fungal isolates in controlling the beetles. In near the future, we will investigate several factors which is possibly related to the control of the forest insect pest using entomopathogenic fungi in field conditions, given the importance of fungal formulation and practical application methods.

원전사고 및 시설보수 과정에서 방출되는 방사성물질 중 137Cs은 토양의 주 오염원 중 하나이다. 세슘으로 인한 토양오염은 주민의 거주 및 공업용지로의 재사용을 위해 제염이 불가피하다. 본 연구에서는 다양한 토양복원 기술 중 국내·외에서 실 제 방사성물질로 오염된 토양에 적용한 사례가 있는 토양세척 기술을 선정하였다. 토양세척 공정은 세척제를 사용하여 토양 과 세슘의 표면장력을 약화시켜 토양과 세슘을 분리하는 원리이다. 이러한 토양세척 공정의 세척수 재사용을 통해 공정효율 을 높이고자 세척수에 응집제를 적용하여 미세토양 및 세슘의 제거 성능 실험을 수행하였다. ICP-OES를 통해 세슘 수용액 에 토양을 첨가하여 세슘을 흡착시킨 후 응집제를 첨가하여 세슘의 농도를 측정하였으며 응집제 적용시 최대 세슘 제거율은 약 88%, 최소는 67%였다. Visual MINTEQ Code를 통한 세슘과 토양과의 종결합을 예측하였으며 탁도 측정을 통해 응집제 투여 후 탁도를 측정하여 세척수의 재사용 여부 및 미세토양 제거율을 분석하였다.

Chemical pesticides have been used for persimmon pest control, however the overuse caused insect resistance andenvironmental toxicity. Herein this work, we investigated the biological potential of eco-friendly organic pesticides (biologicals)and entomopathogenic fungi in controlling persimmon pests, Stathmopoda masinisaa and Riptortus pedetris. A botanicalmixture of Chinese scholar tree, goosefoot and subtripinnata extract, Bacillus thuringesis NT0423 and one isolate of Beauveriabassiana showed high insecticidal activity against the pests in laboratory conditions. The selected botanical extract andmicroorganism were combined with a chemical pesticide (buprofezin+dinotefuran WP) and were assessed their controlefficacy in persimmon fields. Compared to the three times of chemical spray, the combination of more than one timeof chemical spray and the selected biologicals controlled the persimmon pests with an acceptable levels. Consequentlyone time of biological spray can be integrated to the spray program where only chemicals are strongly considered.

Recently, N-terminal pro-brain natriuretic peptide (NTproBNP) has been widely used in the areas of diagnosis, monitoring treatment efficiency, and prognosis for various heart diseases, especially heart failure (HF). In this paper, we try to estimate the prognostic significance of NT-proBNP as a risk evaluation marker in Non-ST-segment Elevation Myocardial Infarction (NSTEMI) patients. We selected NSTEMI patients who underwent percutaneous coronary intervention (PCI) primarily using a drug-eluting stent within 24 h after the onset of chest pain. We compared incidences of major adverse cardiac events (MACE) including death, myocardial infarction (MI), stent thrombosis (ST), and target vessel revascularization (TVR) in two patient groups according to a high or low serum concentration of NT-proBNP, which was measured in the emergency room (ER). We intend to minimize selection bias selecting comparing groups, considering covariate of observed variables together using propensity score matching (PSM) and propensity score weighting (PSW) based on propensity score (PS) to control the difference in baseline characteristics between high- and low NT-proBNP groups. We found that as the log NT-proBNP value increases by 1 through a hazard function of COX’s analysis, the risk of MACE increases by 1.312 times. This result indicated that the NT-proBNP level on ER admission can be used as a significant prognostic indicator to estimate 1 year of MACE in NSTEMI patients who were treated with PCI within 24 h after the onset of chest pain.

The purpose of this study was to investigate the complex ankle exercises on balance. 22 participants (male: 14, female: 8) with functional ankle instability were participated. Functional ankle instability was selected to be less than 24 points using the Cumberland ankle instability tool (CAIT) with people who had severe ankle sprain and then experiencing ankle giving way. A total of 20 minutes performed three times a week for four weeks with muscle strength and balance exercises. Muscle strengthening exercise was performed with Theraband, and balance exercise was performed with unstable support plates. Biodex balance systemⓇ was used to measure static and dynamic balance. The dynamic balance was selected in grade 2, 4, and 8. The static and dynamic balance (grade: 2, 4,and 8) balance was significantly decreased in anterior-posterior, and medial-lateral directions (p<.05). The instability was significantly increased after exercise (p<.05). These results suggest that complex exercises are beneficial to decreasing the functional ankle instability.

We sequenced the complete mitochondrial genome (mitogenome) of Vespa velutina nigrithorax and V. ducalis (Hymenoptera: Vespidae). The genomes were 16,475-bp and 15,779-bp long and contained typical sets of genes. The V. velutina and V. ducalis A+T-rich region was 132-bp long and 166-bp long and was the shortest of all sequenced Vespoidea genomes. Start and stop codons in several Vespa species—including V. velutina and V. ducalis—were diversified, despite these species belonging to the same genus. In comparison with the ancestral mitogenomes, Vespa mitogenomes showed substantial gene rearrangement; however, we detected no gene rearrangement among Vespa species. We conducted phylogenetic reconstruction based on concatenated sequences of 13 PCGs and two rRNAs in available species of Vespoidea—22 species in six subfamilies in two families (Vespidae and Formicidae). The Bayesian inference and maximum likelihood (ML) methods revealed that each family formed strong monophyletic groups.