목적 : 본 연구는 만 50세 이상 성인에서 녹내장, 황반변성, 당뇨병성망막병증의 의사진단여부와 삶의 질의 관 련성을 알아보고자 하였다. 방법 : 국민건강영양조사 제7기(2016~2018) 자료 중 만 50세 이상의 성인으로 녹내장, 황반변성, 당뇨병성망 막병증의 의사진단여부에 따라 현재의 건강상태를 묻는 EQ-5D와의 관계를 분석하였으며, p<0.050인 경우 유의 한 값으로 판단하였다. 결과 : 녹내장, 황반변성, 당뇨병성망막병증에 영향을 주는 요인은 공통적으로 연령이었다. 이들 안질환과 삶의 질의 관계에서 녹내장과 당뇨망막병증은 일상 활동에서의 불편함이 있는 것으로 보였으나 통계적 유의성은 없었 다. 반면 황반변성은 자기관리 능력을 상실시킬 수 있는 위험이 유의하게 큰 것으로 나타났다[Odds ratio: 2.56(95% CI:1.05-6.25)]. 결론 : 본 연구에서 녹내장, 황반변성, 당뇨망막병증과 같은 주요 안질환은 연령과 관련이 있으며, 황반변성은 자기관리능력과 같은 삶의 질을 저하시킨다는 것을 확인하였다

기계식 신축이음장치는 온도변화, 크리프 등에 의한 상부구조 수평변위를 수용하고 불연속면을 연속화시켜 차량의 주행을 원활하게 하는 교량부속장치이다. 하지만 윤하중의 직접재하 및 제설제 등에 노출되어 신축이음장치의 파손, 후타콘크리트 균열 및 탈락 등 많은 문제를 동반하고 있다. 이러한 신축이음장치는 교량 공용기간 중 약 10년 주기로 교체 공사가 필요한 소모성 구조부재이며 매년 동일한 수준의 국가 예산이 지출되고 있는 실정이다. 이에 본 연구에서는 기존의 신축이음 교체 공사 시 기존 교량에 무조인트 교량 시스템을 도입하여 유지관리 비용을 저감할 수 있도록 하였다.

This study was carried out to investigate the effects of wormwood (Artemisia sp.) addition on the growth performance, nutrients utilization and abdominal fat deposition of broiler chickens. Two hundred twenty five and two-day old Arboracre strain male commercial broiler chicks were distributed to 5 treatments with wormwood supplementation levels; C(0%), T₁ (1%), T₂ (3%), T₃ (5%), and T₄ (10%) and with 3 replications each with 5 birds for five weeks. Body weight gain during the experiment was improved in T₁ (1723.0g) compared with that of T₃ (1557.7g) and T₄ (1450.7g) (P＜0.05). Feed intake was significantly (P＜0.05) increased as the levels of wormwood addition increased (C: 2653.8g, T₁: 2852.0, T₂: 2900.3, T₃: 2900.7g, T₄: 2954.7g). Feed conversion rate (feed/gain) was significantly (P＜0.05) increased as the levels of wormwood addition increased (C: 1.55, T₁: 1.66, T₂: 1.70, T₃: 1.86, T₄: 2.04). The days reaching to 2.0㎏ of body weight were expected to be 43.2 days in control, whereas those of group T₁ were reduced to 42.6 days by 0.6 day from control. Nutrient utilization and abdominal fat deposition in the experiment were significantly decreased (P＜0.05) and small intestine contents in the broilers was significantly increased (P＜0.05) as the levels of wormwood addition increased. Therefore, although there was no significant improvement for the performance of broiler chickens with the dietary supplementation of wormwood meal, less than 1% addition of wormwood to broiler diets might have beneficial for human health by reducing the abdominal fat deposition of the broiler chickens.

Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are the most important angiogenic molecules associated with tumor-induced neovascularization. This study was carried out to investigate inhibitory effect of extracts from root of Rehmannia glutinosa LIBOSCHITZ (Rehmannia Radix and Rehmannia Radix Preparata) on endothelial cell proliferation. The methanol extracts from the medicinal herb were fractionated into n-hexane, ethyl acetate, n-butanol and aqueous fractions. Among the four fractions, the n-butanol fraction from R. Radix on exhibited highly effective inhibition (≈79% inhibition) on the binding of KDR/Flk-1-Fc to immobilized VEGF165 and then ethyl acetate fraction from R. Radix (≈45% inhibition) at the concentration of 100 μg/ml. The n-butanol fraction efficiently blocked the VEGF- and bFGF-induced HUVEC proliferation in a dose-dependent manner, but did not affect the growth of HT1080 human fibrosarcoma cells. The n-butanol fraction more efficiently blocked the binding of KDR/Flk-1-Fc to immobilized VEGF165 and VEGF- and bFGF-induced human umbilical vein endothelial cell proliferation than the fraction from R. Radix Preparata. Our results suggest that Rehmannia Radix may be used as a candidate for developing anti-angiogenic agent.

This study was carried out to investigate inhibitory effect of extracts from Artemisia capillaris Thumb. on maltase, sucrase, α-amylase, nonspecific α-glucosidase, and postprandial hyperglycemia. Methanol extract and organic solvent (n-hexane, ethyl acetate, butanol, aqueous) fractions from the medicinal herb were determined for the inhibitory activities against maltase, sucrase and α-amylase. The methanol extract from A. capillaris strongly inhibited maltase (57%) and α-glucosidase (72%) at the concentration of 100 μg/ml. Among the four fractions (n-hexane, ethyl acetate, butanol, aqueous) examined, the butanol fraction from A. capillaris showed potent inhibitory effects on maltase (73%), sucrase (33%), and α-amylase (75%) at the concentration of 100 μg/ml. The butanol fraction from Artemisia capillaris also exhibited significant reductions (20%) of blood glucose elevation in mice loaded with maltose. These results suggest that the extract from Artemisia capillaris can be used as a new nutraceutical for inhibition on postprandial hyperglycemia