In recent years, the world has been undergoing a "century of great changes", and the global political and economic landscape is undergoing profound changes. The development of regional economic and political integration continues to be dynamic. As an important part of the East Asian regional economy, China- Asean (10+1) cooperation is booming, but the regional economic development mechanism in East Asia is not yet sound. In the future, China-Asean (10+1) cooperation should not only be based on enhancing East Asia's comprehensive competitiveness in the global context, but also seize the opportunity of profound changes not seen in a century to further improve the cooperation mechanism.