Apolipoprotein A1 (ApoA1) is the major protein component of high density lipoprotein (HDL) cholesterol in blood, and ApoA1 genetic polymorphisms modulate the blood lipid profiles. This study was conducted in order to investigate the association between three genetic polymorphisms (rs670, rs5069, and rs5070) of ApoA1 and blood lipid profiles in postmenopausal Korean women. A total of 130 post- menopausal women who visited a hospital in order to undergo screening tests were subjects of this study. Genetic polymporphisms and blood lipid profiles were determined using a direct sequencing and spectrophotometric assay, respectively. A significant linkage disequilibrium was observed between all tested single nucleotide polymorphisms. ApoA1 rs5070 genetic polymorphism showed a marginally significant association with HDL cholesterol levels (p=0.066). After adjusting for age, body mass index, smoking, alcohol drinking, medication, hypertension, and diabetes mellitus, we found that the ApoA1 rs5070 genetic polymorphism is a significant determinant of HDL cholesterol levels (β=4.421, p=0.037). According to the results of this study, ApoA1 rs5070 genetic polymorphism may be an important genetic marker associated with HDL cholesterol in postmenopausal Korean women.

In this study, the effects of intake of Acer mono Max. seed oil, and Magnolia denudata seed oil on the lipid levels of mouse blood were compared to those of commercially available vegetable oils. FiveICR mice were each fed a corn oil, Acer mono Max. seed oil, and Magnolia denudata seed oil supplemented diet for a total of 8 weeks. The serum profiles of mice fed Acer mono Max. seed oil and Magnolia denudata seed oil were high in palmitic acid, oleic acid, and linoleic acid. The saturated fatty acid contents of mice fed Acer mono Max. seed oil and Magnolia denudata seed oil were 3.95% and 0.88%, whereas the unsaturated fatty acid contents were 8.71% and 4.60%, respectively. The liver and spleen weights of mice fed Acer mono Max. seed oil were higher than those fed corn oil (p<0.05). Total cholesterol level was highest in mice fed Acer mono Max. seed oil (p<0.05), whereas there were no significant changes in the cholesterol levels of mice fed Magnolia denudata seed oil and corn oil. The HDL-cholesterol levels in mice fed Acer mono Max. seed oil (175.80±27.66 ㎎/㎗) and in those fed Magnolia denudata seed oil (145.20±19.10 ㎎/㎗) were higher compared to those of mice fed corn oil (p<0.05). In conclusion, there were no significant differences in fatty acid composition between mice fed Acer mono Max. seed oil and Magnolia denudata seed oil. Future study on the antioxidant effects of seed oils should be carried out.

에어로빅 댄스에 의한 혈청지질의 변화, 특히 에어로빅 운동 수행기간에 따른 혈청 HDL-C의 변화를 알아보기 위해 서울에 거주하는 35명의 중년여성(35∼45세)을 대상으로 체위측정 및 혈청지질 성분을 분석하였다. 즉 운동을 하지 않는 좌식생활자 8명을 control군으로 하고 에어로빅 댄스를 하는 자 27명을 2∼3개월 수행자군 (AⅠ군), 4∼10개월 수행주군 (AⅡ군), 1년 이상 수행자군(AⅢ군)으로 나누어 그들의 혈청내 total cholesterol, triglyceride, HDL-cholesterol의 농도를 측정한 바 다음과 같은 결과와 결론을 얻었다. 1. 혈청 TG농도는 에어로빅 수행군이 좌식생활자(C군)에 비해 현저하게 낮게 나타났으며(p<0.001) 에어로빅 수행기간이 길수록 낮아졌지만 유의적인 차이는 없었다. 2. 혈청 TC농도는 에어로빅 수행군이 좌식생활자에 비해 낮게(10%) 나타났으나 통계적으로 유의적인 차이는 없었으며 에어로빅 수행기간에 따른 구룹간의 혈청 TC의 농도도 유의적인 차이가 없었다. 3. 혈청 HDL-C농도는 2∼3개월 에어로빅 수행자가 좌식생활자들에 비해 유의하게 높았으며(p<0.05) 에어로빅 수행기간에 의한 구룹간의 HDL-C농도는 유의하게 차이를 나타냈다(p<0.05). 즉 에어로빅 수행 기간이 길수록 혈청 HDL-C농도가 높은 수치로 나타냈다.