3-(2-브로모에틸)인돌을 사용한 2-에티닐피리딘의 4차염화 중합을 통해 새로운 이온성 폴리아세틸렌 유도체 를 합성하였다. 3-(2-브로모에틸)인돌을 사용한 2-에티닐피리딘의 중합은 균일하게 진행되었으며 비교적 높은 수율 로 중합체를 합성할 수 있었다(78%). 3-(2-브로모에틸)인돌에 의한 2-에티닐피리딘의 4차염화 반응에 의해 형성된 N-(3-에틸인돌)-2-에티닐피리디늄 브로마이드의 활성화된 아세틸렌 삼중 결합은 별도의 개시제나 촉매 없이도 중합 반응이 잘 진행됨을 알 수 있었다. 여러 가지 분석 장비를 이용하여 중합체의 구조를 확인한 결과 설계한 인돌 치 환기를 갖는 공액구조 고분자가 생성되었음을 확인할 수 있었다. 이 중합체는 DMF, DMAc, DMSO 등과 같은 극성 유기 용매에 잘 용해하였다. 중합체는 가시광선 영역인 457 nm에서 특징적인 흡수 피크, 600 nm에서 엣지 파장 을 보였다. 중합체의 사이클릭 볼타모그램은 산화와 환원 피크 사이에서 안정한 비가역적 전기화학 거동을 나타내 었다. 스캔 속도가 증가할수록 환원 전류량이 증가하였으며 주 환원 및 산화 피크는 -1.3 V 및 1.1 V에서 관찰되었 다.

Anion assisted [4 + 2] cycloaddition reaction via indolo[2,3]-dienolate by reacting 1,2-dimethylindole-3-carboxaldehyde with aromatic nitriles using lithium diisopropylamide in terahydrofuran, a facile and convenient regiospecific route designed and developed for the synthesis of γ-carbolines.

The cytochrome P-450 enzymes (CYP 2A6) regulate many endogenous signaling molecules and drugs. Aryl alkynes such as 2-ethynylnaphthalene are important P450 inhibitors which have been extensively studied as medicines or as an effective chemical probes for profiling mouse liver microsomal P-450. Here we have synthesized indole-based novel P450 inhibitor, 5-ethynyl indole 3, and showed that it has successfully inhibited CYP 2A6 by chemical inhibition reaction. By using HPLC equipped with a photo diode array(PDA) detector, all of the peaks derived from the enzymatic reaction have been characterized.

3-weeks old Commelina was transferred to and grown in Hoagland solution (Control, 100μM Cd2+, 100μM Cd2++100μM IAA, 100μM Cd2++100μM IAA+2 mM sucrose) for 3 weeks and then the effects of indole acetic acid (IAA) on the accumulation of Cd2+ and growth of Cd2+-treated Commelina were investigated. In the treatment of Cd2+, Cd2+ was uptaked to 1.74, and 51.36 μg/g frwt. at the first week, but for three weeks, 0.51 and 34.53 μg/g frwt. in leaf and stem respectively. When IAA was treated along with Cd2+, Cd2+ was uptaked to 0.18 and 8.63 μg/g frwt. at the first week, and for the incubation of 3 weeks, 0.51 and 45.0 μg/g frwt. in leaf and stem. In case of Cd2++IAA+sucrose, Cd2+ was uptaked to 1.45 and 18.33 μg/g frwt. at the first week, but for 3 weeks, 0.51 and 25.45 μg/g frwt. in leaf and stem. Likewise Cd2+ uptake, the growth was also affected by Cd2+ and IAA. During the incubation of 3 weeks, Cd2+ reduced the stem growth about 8% in all weeks, but the treatment of IAA recovered the inhibition of stem growth caused by Cd2+ to the degree of the control Therefore, it could be concluded that IAA altered the pattern of Cd2+ uptake and the growth which were supposed to change Cd2+ toxicity.