Osteosarcoma (OS) is one of the most common malignant primary bone tumors and NF-κB appears to play a causative role, but the mechanisms are poorly understood. OS is one of the pleomorphic, highly metastasized and invasive neoplasm which is capable to generate osteoid, osteoclast and osteoblast matrix. Its high incidence has been reported in adolescent and children. Cell signal cascade is the pivotal functional mechanism acquired during the differentiation, proliferation, growth and survival of the cells in neoplasm including OS. The major limitation to the success of chemotherapy in OS is the development of multidrug resistance (MDR). Answers to all such queries might come from the knock-in experiments in which the combined approach of miRNAs with NF-κB pathway is put into use. Abnormal miRNAs can modulate several epigenetical switching as a hallmark of number of diseases via different cell signaling. Studies on miRNAs have opened up the new avenues for both the diagnosis and treatment of cancers including OS. Collectively, through the present study an attempt has been made to establish a new systematic approach for the investigation of microRNAs, biophysiological factors and their target pairs with NF-κB to ameliorate oncogenesis with the “bridge between miRNAs and NF- κB”. The application of NF-κB inhibitors in combination with miRNAs is expected to result in a more efficient killing of the cancer stem cells and a slower or less likely recurrence of cancer.

본 논문은 2006년 이후 수년째 산업 기반마저 위태로울 정도로 침체된 국내 아케이드게임에 대해 새로운 규제 패러다임의 필요성에 대한 연구이다. 아케이드 플랫폼은 일체형 특성과 PC기반으로 전환은 아케이드게임에서 사행성 문제가 더 심각할 수 있는 기술적 환경을 제공한다. 아케이드게임 초기부터 문제되는 사행 도구화의 문제를 해결하기 위해서도 기존의 게임물과 사행성에 초점을 맞춘 규제 패러다임은 전환의 필요성이 제기된다. 국내와 유사한 경험을 갖고 새롭게 아케이드게임시장을 선도하고 있는 중국의 사례를 통해, 게임장과 사행행위를 핵심으로 하는 규제 패러다임의 전환에 대한 검토가 필요할 때이다.