Salivary duct carcinoma is a highly malignant tumor that arises from salivary gland. Pathologically, Salivary duct carcinoma is similar to high-grade breast ductal carcinoma. The tumor is commonly associated with pain and facial paralysis and is known to have high rates of recurrence and metastasis. Surgical resection and postoperative radiation is mainstream of the treatment. In this study, we report a case of this tumor which was seen predominantly benign-looking in fine needle aspiration biopsy. The features of this tumor are presented with a review of literature.

Non-keratinizing squamous cell carcinoma (NKSCC) is a rare malignancy of the nose and paranasal sinuses which is characterized by a unique anastomosing ribbon-like growth pattern with absent of limited maturation and keratinization. NKSCC accounts for 10-27% of sinonasal squamous cell carcinomas and some of the NKSCCs are reported to be associated with high risk-HPV infection. Advanced lesion can involve the oral cavity with oral symptoms of palatal bulging, surface ulceration mimicking salivary gland tumors. Herein, we report a case of NKSCC of a 46-year old male, which clinically presented as a bulging mass on the mid palate and mimicked a palatal salivary gland tumor. We reviewed the clinical and histopathological considerations required for differential diagnosis of sinonasal carcinoma involving the oral cavity.

Curcumin (diferuloylmethane), a constituent of turmeric powder derived from the rhizome of Curcuma longa, has been shown to inhibit the growth of various types of cancer cells by regulating cell proliferation and apoptosis. However, a need exists to design more effective analogs because of curcumin's poor intestinal absorption. EF-24 (diphenyl difluoroketone), the monoketone analog of curcumin, has shown good efficacy in anticancer screens. However, the effects of curcumin and EF-24 on salivary gland epidermoid carcinoma cells are not clearly established. The main goal of this study was to investigate the effects of curcumin and EF-24 on cell growth and induction of apoptosis in human salivary gland epidermoid carcinoma cells. Our studies showed that curcumin and EF-24 inhibited the growth of HTB-41 cells in a dose- and time-dependent manner, and the potency of EF-24 was > 34-fold that of curcumin. Treatment with curcumin or EF-24 resulted in nuclear condensation and fragmentation in HTB-41 cells, whereas the control HTB-41 cell nuclei retained their normal regular and oval shape. Curcumin and EF-24 promoted proteolytic cleavages of procaspase-3/-7/-9, resulting in an increase in the amount of cleaved caspase-3/-7/-9 in the HTB-41 cells. Caspase-3 and -7 activities were detected in viable HTB-41 cells treated with curcumin or EF-24. These results suggest that the curcumin and EF-24 inhibit cell proliferation and induce apoptosis in HTB-41 human salivary gland epidermoid carcinoma cells, and that they may have potential properties as an anti-cancer drug therapy.

Epithelial-myoepithelial carcinoma (EMC) is uncommon, low-grade malignant epithelial neoplasm, and composed of ductal and large, clear-staining myoepithelial differentiated cells. we found four cases of EMC patients among those who visited the dental hospital of Seoul National University from 1998 to 2008. Immunohistochemical staining with epithelial and myoepithelial marker was done to verify the characteristic biphasic cell population. In our cases, the mean age of the patients was 61.5 years, which is consistent with previous reports. However, all the patients were female, and submandibular glands were the most affected sites. This is different from other reports that parotid gland was the most affected sites. There was recurrence and metastasis to lung in one out of four cases.

Epithelial myoepithelial carcinoma(EMC) is an uncommon malignant sali va ry gland neoplasm, compri sing about 1% 。f salivar y gland neoplasms, They are histologically composed 01' biphasic cell s such as myoepithelial cells and ductal cells EMC occurs predominantly in the major salivary glands, par t icularly in the par otid gland, They have been reported to occur onJy 10-15% in t he intraoral minor salivary glands, The authors experi enced 4 cases of EMC in Department of Oral Pathology in Seoul National University Dental Hospital from 1995 to 2007‘ and reported them with revi ew of li terature, They occurred at the age [rom 34 to 75 years with average age of 54, Three cases occurred in f'emale and 1 in male, showing predominant occurrence in female, Al I of them occurred in the f100r of mouth Three patients presented localized swollen mass at the time of admission, One patient manifested pain with surface n ecrotic ulcer, and others did not complain any symptoms, The duration of symptoms before diagnosis has ranged f rom three mont hs to 2 years in our cases Microscopically, they growed in double layered ductal structure composed 。f' ductal cells of the inner luminal layer which showed positive immunohistochemical reaction to cytokeratin and rnyoepithelial cells 01' the outer peripheral layer identifi ed by the positive reactivity to S-100 and srnooth muscle ac tin antibody, They did not show perinem al invasion‘ but invasíve growth into adjacent tissue, AII of them did not show in vasion into t he underlying bOl1e While 3 pat ients were treated with total excision of tω110 1' mass wi thout n。 evidence of recurrence a ncl metastasis, a 75 year old patient gave up receiving t reatment at the t irne of diagnos is, and then died 01' the cancer 5 years after init ial diagnosis, It seems that EMC of the intraoral minor salivary gland is a tumor 01' low grade malignancy with low potent ial of recurrence and metastasis